Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women: The swan sleep study

Martica H. Hall, Michele L. Okun, MaryFran Sowers, Karen A. Matthews, Howard M. Kravitz, Kimberly A Hardin, Daniel J. Buysse, Joyce T. Bromberger, Jane F. Owens, Irina Karpov, Mark H. Sanders

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Abstract

Study Objectives: We evaluated associations among subjective and objective measures of sleep and the metabolic syndrome in a multi-ethnic sample of midlife women. Design: Cross-sectional study. Setting: Participants' homes. Participants: Caucasian (n = 158), African American (n = 125), and Chinese women (n = 57); mean age = 51 years. Age range = 46-57 years. Interventions: None. Measurements and Results: Metabolic syndrome was measured in the clinic and sleep quality was assessed by self-report. Indices of sleep duration, continuity/fragmentation, depth, and sleep disordered breathing were assessed by in-home polysomnography (PSG). Covariates included sociodemographics, menopausal status, use of medications that affect sleep, and self-reported health complaints and health behaviors known to influence metabolic syndrome risk. Logistic regression was used to test the hypothesis that the metabolic syndrome would be associated with increased subjective sleep complaints and PSG-assessed sleep disturbances. In univariate analyses, the metabolic syndrome was associated with decreased sleep duration and efficiency and increased NREM beta power and apnea-hypopnea index (AHI). After covariate adjustment, sleep efficiency (odds ratio [OR] = 2.06, 95% confidence interval [CI]: 1.08-3.93), NREM beta power (OR = 2.09, 95% CI: 1.09-3.98), and AHI (OR = 1.86, 95% CI: 1.40-2.48) remained significantly associated with the metabolic syndrome (odds ratio values are expressed in standard deviation units). These relationships did not differ by race. Conclusions: Objective indices of sleep continuity, depth, and sleep disordered breathing are significant correlates of the metabolic syndrome in midlife women, independent of race, menopausal status and other factors that might otherwise account for these relationships.

Original languageEnglish (US)
Pages (from-to)783-790
Number of pages8
JournalSleep
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2012

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Sleep
Odds Ratio
Polysomnography
Sleep Apnea Syndromes
Apnea
Confidence Intervals
Social Adjustment
Health Behavior
African Americans
Self Report
Cross-Sectional Studies
Logistic Models
Health

Keywords

  • Metabolic syndrome
  • Midlife women
  • Obesity
  • Race
  • Sleep

ASJC Scopus subject areas

  • Physiology (medical)
  • Clinical Neurology

Cite this

Hall, M. H., Okun, M. L., Sowers, M., Matthews, K. A., Kravitz, H. M., Hardin, K. A., ... Sanders, M. H. (2012). Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women: The swan sleep study. Sleep, 35(6), 783-790. https://doi.org/10.5665/sleep.1874

Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women : The swan sleep study. / Hall, Martica H.; Okun, Michele L.; Sowers, MaryFran; Matthews, Karen A.; Kravitz, Howard M.; Hardin, Kimberly A; Buysse, Daniel J.; Bromberger, Joyce T.; Owens, Jane F.; Karpov, Irina; Sanders, Mark H.

In: Sleep, Vol. 35, No. 6, 01.06.2012, p. 783-790.

Research output: Contribution to journalArticle

Hall, MH, Okun, ML, Sowers, M, Matthews, KA, Kravitz, HM, Hardin, KA, Buysse, DJ, Bromberger, JT, Owens, JF, Karpov, I & Sanders, MH 2012, 'Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women: The swan sleep study', Sleep, vol. 35, no. 6, pp. 783-790. https://doi.org/10.5665/sleep.1874
Hall, Martica H. ; Okun, Michele L. ; Sowers, MaryFran ; Matthews, Karen A. ; Kravitz, Howard M. ; Hardin, Kimberly A ; Buysse, Daniel J. ; Bromberger, Joyce T. ; Owens, Jane F. ; Karpov, Irina ; Sanders, Mark H. / Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women : The swan sleep study. In: Sleep. 2012 ; Vol. 35, No. 6. pp. 783-790.
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abstract = "Study Objectives: We evaluated associations among subjective and objective measures of sleep and the metabolic syndrome in a multi-ethnic sample of midlife women. Design: Cross-sectional study. Setting: Participants' homes. Participants: Caucasian (n = 158), African American (n = 125), and Chinese women (n = 57); mean age = 51 years. Age range = 46-57 years. Interventions: None. Measurements and Results: Metabolic syndrome was measured in the clinic and sleep quality was assessed by self-report. Indices of sleep duration, continuity/fragmentation, depth, and sleep disordered breathing were assessed by in-home polysomnography (PSG). Covariates included sociodemographics, menopausal status, use of medications that affect sleep, and self-reported health complaints and health behaviors known to influence metabolic syndrome risk. Logistic regression was used to test the hypothesis that the metabolic syndrome would be associated with increased subjective sleep complaints and PSG-assessed sleep disturbances. In univariate analyses, the metabolic syndrome was associated with decreased sleep duration and efficiency and increased NREM beta power and apnea-hypopnea index (AHI). After covariate adjustment, sleep efficiency (odds ratio [OR] = 2.06, 95{\%} confidence interval [CI]: 1.08-3.93), NREM beta power (OR = 2.09, 95{\%} CI: 1.09-3.98), and AHI (OR = 1.86, 95{\%} CI: 1.40-2.48) remained significantly associated with the metabolic syndrome (odds ratio values are expressed in standard deviation units). These relationships did not differ by race. Conclusions: Objective indices of sleep continuity, depth, and sleep disordered breathing are significant correlates of the metabolic syndrome in midlife women, independent of race, menopausal status and other factors that might otherwise account for these relationships.",
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