Abstract
Chondrosarcomas are indolent but invasive chondroid malignancies that can form in the skull base. Standard management of chondrosarcoma involves surgical resection and adjuvant radiation therapy. This review evaluates evidence from the literature to assess the importance of the surgical approach and extent of resection on outcomes for patients with skull base chondrosarcoma. Also evaluated is the ability of the multiple modalities of radiation therapy, such as conventional fractionated radiotherapy, proton beam, and stereotactic radiosurgery, to control tumor growth. Finally, emerging therapies for the treatment of skull-base chondrosarcoma are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 89-96 |
| Number of pages | 8 |
| Journal | Neurosurgery Clinics of North America |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2013 |
| Externally published | Yes |
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Keywords
- Chondrosarcoma
- Microsurgery
- Radiotherapy
- Skull base
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
Cite this
Skull Base Chondrosarcoma. Evidence-Based Treatment Paradigms. / Bloch, Orin; Parsa, Andrew T.
In: Neurosurgery Clinics of North America, Vol. 24, No. 1, 01.01.2013, p. 89-96.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Skull Base Chondrosarcoma. Evidence-Based Treatment Paradigms.
AU - Bloch, Orin
AU - Parsa, Andrew T.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Chondrosarcomas are indolent but invasive chondroid malignancies that can form in the skull base. Standard management of chondrosarcoma involves surgical resection and adjuvant radiation therapy. This review evaluates evidence from the literature to assess the importance of the surgical approach and extent of resection on outcomes for patients with skull base chondrosarcoma. Also evaluated is the ability of the multiple modalities of radiation therapy, such as conventional fractionated radiotherapy, proton beam, and stereotactic radiosurgery, to control tumor growth. Finally, emerging therapies for the treatment of skull-base chondrosarcoma are discussed.
AB - Chondrosarcomas are indolent but invasive chondroid malignancies that can form in the skull base. Standard management of chondrosarcoma involves surgical resection and adjuvant radiation therapy. This review evaluates evidence from the literature to assess the importance of the surgical approach and extent of resection on outcomes for patients with skull base chondrosarcoma. Also evaluated is the ability of the multiple modalities of radiation therapy, such as conventional fractionated radiotherapy, proton beam, and stereotactic radiosurgery, to control tumor growth. Finally, emerging therapies for the treatment of skull-base chondrosarcoma are discussed.
KW - Chondrosarcoma
KW - Microsurgery
KW - Radiotherapy
KW - Skull base
UR - http://www.scopus.com/inward/record.url?scp=84869801943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869801943&partnerID=8YFLogxK
U2 - 10.1016/j.nec.2012.08.002
DO - 10.1016/j.nec.2012.08.002
M3 - Review article
C2 - 23174360
AN - SCOPUS:84869801943
VL - 24
SP - 89
EP - 96
JO - Neurosurgery Clinics of North America
JF - Neurosurgery Clinics of North America
SN - 1042-3680
IS - 1
ER -