Skin-to-skin contact after birth and the natural course of neurosteroid levels in healthy term newborns

K. R. McCallie, N. W. Gaikwad, M. E. Castillo Cuadrado, Monica R Aleman, John E Madigan, D. K. Stevenson, V. K. Bhutani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To determine the postnatal course of neurosteroid levels in relation to gender, mode of delivery and the extent of skin-to-skin (STS) contact during the first days of life in healthy term newborns. Study Design: Prospective observational study of 39 neonates in which parents recorded total duration of STS in the first 2 days and nine neurosteroids (dehydroepiandrosterone-sulfate, progesterone, pregnenolone, pregnenolone-sulfate, allopregnanolone, isopregnanolone, epipregnanolone, pregnanolone and pregnanolone-sulfate) were assayed from blood samples at birth and at 1-2 days of age. Results: All nine neurosteroid levels declined significantly during the first 2 days of life. Gender did not significantly affect the change in neurosteroid levels. The decline in neurosteroid levels was generally more pronounced in vaginal deliveries, and there was a trend toward a larger decline with more exposure to STS. Conclusion: Ongoing studies may better characterize the role of neurosteroids and the influence of STS in more critically ill and premature neonates.

Original languageEnglish (US)
Pages (from-to)591-595
Number of pages5
JournalJournal of Perinatology
Volume37
Issue number5
DOIs
StatePublished - May 1 2017

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Neurotransmitter Agents
Parturition
Newborn Infant
Pregnanolone
Skin
Pregnenolone
Dehydroepiandrosterone Sulfate
Interpersonal Relations
Critical Illness
Sulfates
Observational Studies
Progesterone
Parents
Prospective Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Skin-to-skin contact after birth and the natural course of neurosteroid levels in healthy term newborns. / McCallie, K. R.; Gaikwad, N. W.; Castillo Cuadrado, M. E.; Aleman, Monica R; Madigan, John E; Stevenson, D. K.; Bhutani, V. K.

In: Journal of Perinatology, Vol. 37, No. 5, 01.05.2017, p. 591-595.

Research output: Contribution to journalArticle

McCallie, K. R. ; Gaikwad, N. W. ; Castillo Cuadrado, M. E. ; Aleman, Monica R ; Madigan, John E ; Stevenson, D. K. ; Bhutani, V. K. / Skin-to-skin contact after birth and the natural course of neurosteroid levels in healthy term newborns. In: Journal of Perinatology. 2017 ; Vol. 37, No. 5. pp. 591-595.
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