Skin cooling attenuates rat dorsal horn neuronal responses to intracutaneous histamine

Steven L. Jinks, Earl Carstens

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Itch sensation is reduced by cooling the skin. We tested whether lowering skin temperature attenuates responses of spinal dorsal horn neurons elicited by intracutaneous (i.c.) microinjection of histamine in anesthetized rats. Cooling the skin to 3°C significantly and reproducibly reduced (to a mean of 48%) i.c. histamine-evoked responses in 20 of 24 wide dynamic range- type dorsal horn neurons. Histamine-evoked responses recovered to control levels after rewarming the skin. Assuming that such neurons play a role in signaling itch, depression of their responses during skin cooling may account for the psychophysical observation that skin cooling relieves itch in humans.

Original languageEnglish (US)
Pages (from-to)4145-4149
Number of pages5
JournalNeuroReport
Volume9
Issue number18
StatePublished - Dec 21 1998

Keywords

  • Cooling
  • Histamine
  • Itch
  • Skin
  • Spinal dorsal horn neuron

ASJC Scopus subject areas

  • Neuroscience(all)

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