Skewing of X chromosome inactivation in autoimmunity

Pietro Invernizzi, Simone Pasini, Carlo Selmi, Monica Miozzo, Mauro Podda

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Approximately 5% of the population in Western countries is affected by autoimmune diseases (AID), with a significantly higher prevalence in women. Genetic factors are known to be crucial determinants of susceptibility as shown by family and twin studies, although no specific genes predisposing women to autoimmunity have been identified thus far. Several studies indicate that X chromosome abnormalities, such as inactivation patterns, characterize some female-predominant AID. We herein review the most recent evidence on the role of the X chromosome in the breakdown of immune tolerance and discuss its potential implications. Future efforts will help to identify specific X chromosome regions containing candidate genes for disease susceptibility.

Original languageEnglish (US)
Pages (from-to)272-277
Number of pages6
JournalAutoimmunity
Volume41
Issue number4
DOIs
StatePublished - Jun 2008
Externally publishedYes

Keywords

  • Autoimmune diseases
  • Autoimmunity
  • Epigenetic factors
  • Genetic factors
  • X chromosome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Skewing of X chromosome inactivation in autoimmunity'. Together they form a unique fingerprint.

  • Cite this

    Invernizzi, P., Pasini, S., Selmi, C., Miozzo, M., & Podda, M. (2008). Skewing of X chromosome inactivation in autoimmunity. Autoimmunity, 41(4), 272-277. https://doi.org/10.1080/08916930802024574