Skewing of X chromosome inactivation in autoimmunity

Pietro Invernizzi, Simone Pasini, Carlo Selmi, Monica Miozzo, Mauro Podda

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Approximately 5% of the population in Western countries is affected by autoimmune diseases (AID), with a significantly higher prevalence in women. Genetic factors are known to be crucial determinants of susceptibility as shown by family and twin studies, although no specific genes predisposing women to autoimmunity have been identified thus far. Several studies indicate that X chromosome abnormalities, such as inactivation patterns, characterize some female-predominant AID. We herein review the most recent evidence on the role of the X chromosome in the breakdown of immune tolerance and discuss its potential implications. Future efforts will help to identify specific X chromosome regions containing candidate genes for disease susceptibility.

Original languageEnglish (US)
Pages (from-to)272-277
Number of pages6
JournalAutoimmunity
Volume41
Issue number4
DOIs
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

X Chromosome Inactivation
X Chromosome
Autoimmunity
Autoimmune Diseases
Immune Tolerance
Twin Studies
Disease Susceptibility
Chromosome Aberrations
Genes
Population

Keywords

  • Autoimmune diseases
  • Autoimmunity
  • Epigenetic factors
  • Genetic factors
  • X chromosome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Invernizzi, P., Pasini, S., Selmi, C., Miozzo, M., & Podda, M. (2008). Skewing of X chromosome inactivation in autoimmunity. Autoimmunity, 41(4), 272-277. https://doi.org/10.1080/08916930802024574

Skewing of X chromosome inactivation in autoimmunity. / Invernizzi, Pietro; Pasini, Simone; Selmi, Carlo; Miozzo, Monica; Podda, Mauro.

In: Autoimmunity, Vol. 41, No. 4, 06.2008, p. 272-277.

Research output: Contribution to journalArticle

Invernizzi, P, Pasini, S, Selmi, C, Miozzo, M & Podda, M 2008, 'Skewing of X chromosome inactivation in autoimmunity', Autoimmunity, vol. 41, no. 4, pp. 272-277. https://doi.org/10.1080/08916930802024574
Invernizzi P, Pasini S, Selmi C, Miozzo M, Podda M. Skewing of X chromosome inactivation in autoimmunity. Autoimmunity. 2008 Jun;41(4):272-277. https://doi.org/10.1080/08916930802024574
Invernizzi, Pietro ; Pasini, Simone ; Selmi, Carlo ; Miozzo, Monica ; Podda, Mauro. / Skewing of X chromosome inactivation in autoimmunity. In: Autoimmunity. 2008 ; Vol. 41, No. 4. pp. 272-277.
@article{df53f3f0b473409c83f959c119a1fd83,
title = "Skewing of X chromosome inactivation in autoimmunity",
abstract = "Approximately 5{\%} of the population in Western countries is affected by autoimmune diseases (AID), with a significantly higher prevalence in women. Genetic factors are known to be crucial determinants of susceptibility as shown by family and twin studies, although no specific genes predisposing women to autoimmunity have been identified thus far. Several studies indicate that X chromosome abnormalities, such as inactivation patterns, characterize some female-predominant AID. We herein review the most recent evidence on the role of the X chromosome in the breakdown of immune tolerance and discuss its potential implications. Future efforts will help to identify specific X chromosome regions containing candidate genes for disease susceptibility.",
keywords = "Autoimmune diseases, Autoimmunity, Epigenetic factors, Genetic factors, X chromosome",
author = "Pietro Invernizzi and Simone Pasini and Carlo Selmi and Monica Miozzo and Mauro Podda",
year = "2008",
month = "6",
doi = "10.1080/08916930802024574",
language = "English (US)",
volume = "41",
pages = "272--277",
journal = "Autoimmunity",
issn = "0891-6934",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Skewing of X chromosome inactivation in autoimmunity

AU - Invernizzi, Pietro

AU - Pasini, Simone

AU - Selmi, Carlo

AU - Miozzo, Monica

AU - Podda, Mauro

PY - 2008/6

Y1 - 2008/6

N2 - Approximately 5% of the population in Western countries is affected by autoimmune diseases (AID), with a significantly higher prevalence in women. Genetic factors are known to be crucial determinants of susceptibility as shown by family and twin studies, although no specific genes predisposing women to autoimmunity have been identified thus far. Several studies indicate that X chromosome abnormalities, such as inactivation patterns, characterize some female-predominant AID. We herein review the most recent evidence on the role of the X chromosome in the breakdown of immune tolerance and discuss its potential implications. Future efforts will help to identify specific X chromosome regions containing candidate genes for disease susceptibility.

AB - Approximately 5% of the population in Western countries is affected by autoimmune diseases (AID), with a significantly higher prevalence in women. Genetic factors are known to be crucial determinants of susceptibility as shown by family and twin studies, although no specific genes predisposing women to autoimmunity have been identified thus far. Several studies indicate that X chromosome abnormalities, such as inactivation patterns, characterize some female-predominant AID. We herein review the most recent evidence on the role of the X chromosome in the breakdown of immune tolerance and discuss its potential implications. Future efforts will help to identify specific X chromosome regions containing candidate genes for disease susceptibility.

KW - Autoimmune diseases

KW - Autoimmunity

KW - Epigenetic factors

KW - Genetic factors

KW - X chromosome

UR - http://www.scopus.com/inward/record.url?scp=42649143294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42649143294&partnerID=8YFLogxK

U2 - 10.1080/08916930802024574

DO - 10.1080/08916930802024574

M3 - Article

C2 - 18432407

AN - SCOPUS:42649143294

VL - 41

SP - 272

EP - 277

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

IS - 4

ER -