Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse

S. J. Valberg, Gary Carlson, G. H. Cardinet, E. K. Birks, James H Jones, A. Chomyn, S. Dimauro

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Although exertional myopathies are commonly recognized in horses, specific etiologies have not been identified. This is the first report in the horse of a deficiency of Complex I respiratory chain enzyme associated with profound exercise intolerance. Physical examination, routine blood tests, endoscopy, and ultrasonograms of the heart and iliac arteries were unremarkable. With slow, incremental exercise (speeds 1.5-7 m/s), the Arabian mare showed a marked lactic acidosis, increased mixed venous PVO2, and little change in oxygen consumption. Muscle biopsies contained large accumulations of mitochondria with bizarre cristae formations. Biochemical analyses revealed a very low activity of the first enzyme complex in the mitochondrial respiratory chain (NADH CoQ reductase). The exercise intolerance and muscle stiffness in this horse were attributed to a profound lactic acidosis resulting from impaired oxidative energy metabolism during exercise.

Original languageEnglish (US)
Pages (from-to)305-312
Number of pages8
JournalMuscle and Nerve
Volume17
Issue number3
StatePublished - 1994

Fingerprint

Mitochondrial Myopathies
Horses
Lactic Acidosis
Skeletal Muscle
Electron Transport
Electron Transport Complex I
Muscles
Iliac Artery
Hematologic Tests
Muscular Diseases
Enzymes
Oxygen Consumption
Energy Metabolism
Endoscopy
Physical Examination
Mitochondria
Biopsy

Keywords

  • Complex I
  • horse
  • mitochondria
  • muscle
  • myopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Valberg, S. J., Carlson, G., Cardinet, G. H., Birks, E. K., Jones, J. H., Chomyn, A., & Dimauro, S. (1994). Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse. Muscle and Nerve, 17(3), 305-312.

Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse. / Valberg, S. J.; Carlson, Gary; Cardinet, G. H.; Birks, E. K.; Jones, James H; Chomyn, A.; Dimauro, S.

In: Muscle and Nerve, Vol. 17, No. 3, 1994, p. 305-312.

Research output: Contribution to journalArticle

Valberg, SJ, Carlson, G, Cardinet, GH, Birks, EK, Jones, JH, Chomyn, A & Dimauro, S 1994, 'Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse', Muscle and Nerve, vol. 17, no. 3, pp. 305-312.
Valberg, S. J. ; Carlson, Gary ; Cardinet, G. H. ; Birks, E. K. ; Jones, James H ; Chomyn, A. ; Dimauro, S. / Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse. In: Muscle and Nerve. 1994 ; Vol. 17, No. 3. pp. 305-312.
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