Skeletal muscle

Length-dependent effects of potentiating agents

J. Rafael Lopez, Laurel A. Wanek, Stuart R. Taylor

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The ability of vertebrate skeletal muscle to contract more vigorously than normal in the presence of potentiating agents depends on the initial length of a muscle cell. Other factors such as the intracellular calcium ion transient, temperature, chemical nature of the potentiating agent, and the ratio of intrinsic twitch to tetanic force influence the degree of contractile potentiation but cannot account for the length dependence. At least part of a muscle cell seems normally less than fully active during contractions not only at short lengths but also at optimal sarcomere lengths.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalScience
Volume214
Issue number4516
StatePublished - 1981
Externally publishedYes

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Muscle Cells
Skeletal Muscle
Sarcomeres
Vertebrates
Ions
Calcium
Temperature

ASJC Scopus subject areas

  • General

Cite this

Lopez, J. R., Wanek, L. A., & Taylor, S. R. (1981). Skeletal muscle: Length-dependent effects of potentiating agents. Science, 214(4516), 79-82.

Skeletal muscle : Length-dependent effects of potentiating agents. / Lopez, J. Rafael; Wanek, Laurel A.; Taylor, Stuart R.

In: Science, Vol. 214, No. 4516, 1981, p. 79-82.

Research output: Contribution to journalArticle

Lopez, JR, Wanek, LA & Taylor, SR 1981, 'Skeletal muscle: Length-dependent effects of potentiating agents', Science, vol. 214, no. 4516, pp. 79-82.
Lopez JR, Wanek LA, Taylor SR. Skeletal muscle: Length-dependent effects of potentiating agents. Science. 1981;214(4516):79-82.
Lopez, J. Rafael ; Wanek, Laurel A. ; Taylor, Stuart R. / Skeletal muscle : Length-dependent effects of potentiating agents. In: Science. 1981 ; Vol. 214, No. 4516. pp. 79-82.
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