Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

Sue C. Bodine, Leslie M. Baehr

Research output: Contribution to journalArticle

291 Scopus citations

Abstract

Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased transcriptionally in skeletal muscle under atrophy-inducing conditions, making them excellent markers of muscle atrophy. In the past 10 years much has been published about MuRF1 and MAFbx with respect to their mRNA expression patterns under atrophy-inducing conditions, their transcriptional regulation, and their putative substrates. However, much remains to be learned about the physiological role of both genes in the regulation of mass and other cellular functions in striated muscle. Although both MuRF1 and MAFbx are enriched in skeletal, cardiac, and smooth muscle, this review will focus on the current understanding of MuRF1 and MAFbx in skeletal muscle, highlighting the critical questions that remain to be answered.

Original languageEnglish (US)
Pages (from-to)E469-E484
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume307
Issue number6
DOIs
StatePublished - Sep 15 2014

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Keywords

  • Atrogenes
  • Muscle atrophy F-box
  • Muscle RING finger 1
  • Muscle sparing
  • Protein quality control
  • Ubiquitin proteasome system

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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