Abstract
Sjogren's syndrome is well known for the presence of antibodies directed at specific nuclear antigens. However, the presence of antibodies reacting with a variety of other self antigens, including antimitochondrial antibodies, has often been reported although their significance is unknown. Moreover, patients with Sjogren's syndrome have been occasionally reported to be concordant with primary biliary cirrhosis. To address this issue we studied in a group of 96 patients with Sjogren's syndrome the presence of autoantibodies to the dihydrolipoamide acetyltransferases of both pyruvate dehydrogenase and branch chain ketoacid dehydrogenase and to α-ketoglutarate dehydrogenase; these latter enzymes are the mitochondrial target antigens of primary biliary cirrhosis. We report that 7 of the 96 patients reacted with the mitochondrial antigens that are prominent in primary biliary cirrhosis. Moreover, in those patients showing reactivity with mitoch
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1453-1457 |
| Number of pages | 5 |
| Journal | Journal of Rheumatology |
| Volume | 17 |
| Issue number | 11 |
| State | Published - 1990 |
Fingerprint
Keywords
- Antimitochondrial antibodies
- Autoantibodies
- Prevalence
- Primary biliary cirrhosis
- Sjogren's syndrome
- Western blot
ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Sjogren's syndrome and primary biliary cirrhosis : Presence of autoantibodies to purified mitochondrial 2-OXO acid dehydrogenases. / Fujikura, S.; Davis, P. A.; Prindiville, Thomas P; Leung, Patrick S; Fox, R. I.; Gershwin, M. Eric.
In: Journal of Rheumatology, Vol. 17, No. 11, 1990, p. 1453-1457.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sjogren's syndrome and primary biliary cirrhosis
T2 - Presence of autoantibodies to purified mitochondrial 2-OXO acid dehydrogenases
AU - Fujikura, S.
AU - Davis, P. A.
AU - Prindiville, Thomas P
AU - Leung, Patrick S
AU - Fox, R. I.
AU - Gershwin, M. Eric
PY - 1990
Y1 - 1990
N2 - Sjogren's syndrome is well known for the presence of antibodies directed at specific nuclear antigens. However, the presence of antibodies reacting with a variety of other self antigens, including antimitochondrial antibodies, has often been reported although their significance is unknown. Moreover, patients with Sjogren's syndrome have been occasionally reported to be concordant with primary biliary cirrhosis. To address this issue we studied in a group of 96 patients with Sjogren's syndrome the presence of autoantibodies to the dihydrolipoamide acetyltransferases of both pyruvate dehydrogenase and branch chain ketoacid dehydrogenase and to α-ketoglutarate dehydrogenase; these latter enzymes are the mitochondrial target antigens of primary biliary cirrhosis. We report that 7 of the 96 patients reacted with the mitochondrial antigens that are prominent in primary biliary cirrhosis. Moreover, in those patients showing reactivity with mitoch
AB - Sjogren's syndrome is well known for the presence of antibodies directed at specific nuclear antigens. However, the presence of antibodies reacting with a variety of other self antigens, including antimitochondrial antibodies, has often been reported although their significance is unknown. Moreover, patients with Sjogren's syndrome have been occasionally reported to be concordant with primary biliary cirrhosis. To address this issue we studied in a group of 96 patients with Sjogren's syndrome the presence of autoantibodies to the dihydrolipoamide acetyltransferases of both pyruvate dehydrogenase and branch chain ketoacid dehydrogenase and to α-ketoglutarate dehydrogenase; these latter enzymes are the mitochondrial target antigens of primary biliary cirrhosis. We report that 7 of the 96 patients reacted with the mitochondrial antigens that are prominent in primary biliary cirrhosis. Moreover, in those patients showing reactivity with mitoch
KW - Antimitochondrial antibodies
KW - Autoantibodies
KW - Prevalence
KW - Primary biliary cirrhosis
KW - Sjogren's syndrome
KW - Western blot
UR - http://www.scopus.com/inward/record.url?scp=0025191644&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025191644&partnerID=8YFLogxK
M3 - Article
C2 - 1703233
AN - SCOPUS:0025191644
VL - 17
SP - 1453
EP - 1457
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 11
ER -