Abstract
Objective: To assess 6-year contraceptive efficacy and safety of a levonorgestrel 52 mg intrauterine system (IUS). Study Design: We assessed pregnancy rates through 72 months in women aged 16–35 years at enrollment and safety in all participants (aged 16–45 years, n = 1751) in an ongoing 10-year phase-3 trial. Results: Over six years, nine pregnancies occurred (none in year 6) for a life-table pregnancy rate of 0.87 (95% CI 0.44–1.70). Adverse event rates remain low through 6 or more years of use. Two expulsions occurred in year 6. Conclusion: This levonorgestrel 52 mg IUS is a highly effective and safe contraceptive over 6 years of use. Implications: The levonorgestrel 52 mg IUS shows high 6-year contraceptive efficacy and a low rate of adverse events through 6 or more years of use.
| Original language | English (US) |
|---|---|
| Journal | Contraception |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Efficacy
- Intrauterine system
- Levonorgestrel
- Liletta
- Safety
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
Cite this
Six-year contraceptive efficacy and continued safety of a levonorgestrel 52 mg intrauterine system. / Westhoff, Carolyn L.; Keder, Lisa M.; Gangestad, Angelina; Teal, Stephanie B.; Olariu, Andrea I.; Creinin, Mitchell D.
In: Contraception, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Six-year contraceptive efficacy and continued safety of a levonorgestrel 52 mg intrauterine system
AU - Westhoff, Carolyn L.
AU - Keder, Lisa M.
AU - Gangestad, Angelina
AU - Teal, Stephanie B.
AU - Olariu, Andrea I.
AU - Creinin, Mitchell D.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objective: To assess 6-year contraceptive efficacy and safety of a levonorgestrel 52 mg intrauterine system (IUS). Study Design: We assessed pregnancy rates through 72 months in women aged 16–35 years at enrollment and safety in all participants (aged 16–45 years, n = 1751) in an ongoing 10-year phase-3 trial. Results: Over six years, nine pregnancies occurred (none in year 6) for a life-table pregnancy rate of 0.87 (95% CI 0.44–1.70). Adverse event rates remain low through 6 or more years of use. Two expulsions occurred in year 6. Conclusion: This levonorgestrel 52 mg IUS is a highly effective and safe contraceptive over 6 years of use. Implications: The levonorgestrel 52 mg IUS shows high 6-year contraceptive efficacy and a low rate of adverse events through 6 or more years of use.
AB - Objective: To assess 6-year contraceptive efficacy and safety of a levonorgestrel 52 mg intrauterine system (IUS). Study Design: We assessed pregnancy rates through 72 months in women aged 16–35 years at enrollment and safety in all participants (aged 16–45 years, n = 1751) in an ongoing 10-year phase-3 trial. Results: Over six years, nine pregnancies occurred (none in year 6) for a life-table pregnancy rate of 0.87 (95% CI 0.44–1.70). Adverse event rates remain low through 6 or more years of use. Two expulsions occurred in year 6. Conclusion: This levonorgestrel 52 mg IUS is a highly effective and safe contraceptive over 6 years of use. Implications: The levonorgestrel 52 mg IUS shows high 6-year contraceptive efficacy and a low rate of adverse events through 6 or more years of use.
KW - Efficacy
KW - Intrauterine system
KW - Levonorgestrel
KW - Liletta
KW - Safety
UR - http://www.scopus.com/inward/record.url?scp=85076574430&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076574430&partnerID=8YFLogxK
U2 - 10.1016/j.contraception.2019.10.010
DO - 10.1016/j.contraception.2019.10.010
M3 - Article
C2 - 31786203
AN - SCOPUS:85076574430
JO - Contraception
JF - Contraception
SN - 0010-7824
ER -