SIV-infection-driven changes of pattern recognition receptor expression in mesenteric lymph nodes and gut microbiota dysbiosis

Tiffany W. Glavan, Christopher A. Gaulke, Lauren A. Hirao, Sumathi Sankaran-Walters, Satya Dandekar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The impact of HIV infection on pattern recognition receptor (PRR) expression in gut-associated lymphoid tissue and its association with dysbiosis is not well understood. Methods: PRR and cytokine gene expression were examined in mesenteric lymph nodes (mLN) of rhesus macaques during acute and chronic (untreated and early antiretroviral (ART) treated) infections. Gene expression was correlated with microbial abundance in the gut and immune activation. Results: PRR expression rapidly increases during acute infection and is significantly decreased in chronic infection. Early ART maintains elevated PRR expression. Correlation analysis revealed three distinct groups of bacterial taxa that were associated with gene expression changes in infection. Conclusions: PRR and cytokine gene expression in the gut-draining mLN are rapidly modulated in response to viral infection and are correlated with gut dysbiosis. These data suggest that the dysregulation of PRR and related cytokine expression may contribute to chronic immune activation in SIV infection.

Original languageEnglish (US)
Pages (from-to)241-252
Number of pages12
JournalJournal of Medical Primatology
Volume44
Issue number5
DOIs
StatePublished - Oct 1 2015

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Dysbiosis
Pattern Recognition Receptors
intestinal microorganisms
lymph nodes
Lymph Nodes
receptors
Infection
infection
Gene Expression
gene expression
cytokines
digestive system
Cytokines
HIV infections
Lymphoid Tissue
Virus Diseases
Macaca mulatta
HIV Infections
Gastrointestinal Microbiome

Keywords

  • Cytokines
  • GALT
  • Microbiota
  • SIV
  • Toll like receptors

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

SIV-infection-driven changes of pattern recognition receptor expression in mesenteric lymph nodes and gut microbiota dysbiosis. / Glavan, Tiffany W.; Gaulke, Christopher A.; Hirao, Lauren A.; Sankaran-Walters, Sumathi; Dandekar, Satya.

In: Journal of Medical Primatology, Vol. 44, No. 5, 01.10.2015, p. 241-252.

Research output: Contribution to journalArticle

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