SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques.

Jose V Torres, D. E. Anderson, A. Malley, B. Banapour, M. K. Axthelm, E. Benjamini, M. B. Gardner

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We analyzed SIV-specific monkey sera to localize B-cell epitopes of the envelope glycoprotein of SIV (gp130), using overlapping synthetic peptides representing the entire SIV gp130 protein and sera from experimentally infected monkeys and monkeys immunized with whole, inactivated SIV. A B-cell epitope which induces neutralizing antibody production and T-cell responses was characterized as well as a new B-cell epitope and a previously described neutralizing epitopes. Vaccinated monkey sera recognize the three epitopes differentially relative to unimmunized controls, and a correlation appears to exist between degree of cross-neutralization by infected monkey sera and degree of binding to these three regions.

Original languageEnglish (US)
Pages (from-to)129-137
Number of pages9
JournalJournal of Medical Primatology
Volume22
Issue number2-3
StatePublished - Feb 1993

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Torres, J. V., Anderson, D. E., Malley, A., Banapour, B., Axthelm, M. K., Benjamini, E., & Gardner, M. B. (1993). SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques. Journal of Medical Primatology, 22(2-3), 129-137.