Site-specific modification of Epstein-Barr virus-encoded RNA 1 with N 2-benzylguanosine limits the binding sites occupied by PKR

Sujiet Puthenveetil, Eduardo A. Véliz, Peter A. Beal

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Examining viral decoys: Epstein-Barr virus (EBV) generates small RNA inhibitors of the human RNA-dependent protein kinase (PKR). We demonstrate that chemical synthesis of analogues of the EBV PKR inhibitor EBER1 bearing single N2-benzylguanosine substitutions (BnG6 or BnG29) can be used to control the way PKR binds this RNA.

Original languageEnglish (US)
Pages (from-to)383-386
Number of pages4
JournalChemBioChem
Volume5
Issue number3
DOIs
StatePublished - Mar 5 2004
Externally publishedYes

Keywords

  • Epstein-Barr virus
  • Nucleic acids
  • Proteins
  • RNA recognition
  • RNA-dependent protein kinase

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

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