Site of action of anorectic drugs: Glucoprivic- versus food deprivation-induced feeding

Itzchak Angel, Jill A. Stivers, Steven M. Paul, Jacqueline Crawley

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Feeding induced by 2-deoxyglucose was compared with feeding induced by food deprivation in terms of antagonism by anorectic drugs and of anatomical site of action. Glucoprivic feeding was completely blocked by microinjection of amphetamine, fenfluramine, and mazindol into the paraventricular nucleus of the hypothalamus (PVN). Deprivation-induced feeding was not blocked by amphetamine, fenfluramine, or mazindol microinjected into the PVN. Neither the feeding induced by 2-deoxyglucose nor its reversal by amphetamine were blocked by pretreatment with the β-adrenergic antagonist, propranolol. Amphetamine and fenfluramine blocked both glucoprivic- and deprivation-induced feeding when microinjected into the perifornical region of the lateral hypothalamus. These data suggest that food consumption induced by 2-deoxyglucose treatment can be antagonized by anorectic drugs acting at recognition sites present in several hypothalamic nuclei, while deprivation-induced feeding acts through different receptor mechanisms which may be specific to the perifornical region of the lateral hypothalamus.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume27
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • 2-Deoxy-D-glucose
  • Amphetamine
  • Anorectic drugs
  • Glucoprivic feeding
  • Hypothalamus
  • Paraventricular hypothalamic nucleus

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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