Abstract
Feeding induced by 2-deoxyglucose was compared with feeding induced by food deprivation in terms of antagonism by anorectic drugs and of anatomical site of action. Glucoprivic feeding was completely blocked by microinjection of amphetamine, fenfluramine, and mazindol into the paraventricular nucleus of the hypothalamus (PVN). Deprivation-induced feeding was not blocked by amphetamine, fenfluramine, or mazindol microinjected into the PVN. Neither the feeding induced by 2-deoxyglucose nor its reversal by amphetamine were blocked by pretreatment with the β-adrenergic antagonist, propranolol. Amphetamine and fenfluramine blocked both glucoprivic- and deprivation-induced feeding when microinjected into the perifornical region of the lateral hypothalamus. These data suggest that food consumption induced by 2-deoxyglucose treatment can be antagonized by anorectic drugs acting at recognition sites present in several hypothalamic nuclei, while deprivation-induced feeding acts through different receptor mechanisms which may be specific to the perifornical region of the lateral hypothalamus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 291-297 |
| Number of pages | 7 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |
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Keywords
- 2-Deoxy-D-glucose
- Amphetamine
- Anorectic drugs
- Glucoprivic feeding
- Hypothalamus
- Paraventricular hypothalamic nucleus
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Site of action of anorectic drugs : Glucoprivic- versus food deprivation-induced feeding. / Angel, Itzchak; Stivers, Jill A.; Paul, Steven M.; Crawley, Jacqueline.
In: Pharmacology, Biochemistry and Behavior, Vol. 27, No. 2, 1987, p. 291-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Site of action of anorectic drugs
T2 - Glucoprivic- versus food deprivation-induced feeding
AU - Angel, Itzchak
AU - Stivers, Jill A.
AU - Paul, Steven M.
AU - Crawley, Jacqueline
PY - 1987
Y1 - 1987
N2 - Feeding induced by 2-deoxyglucose was compared with feeding induced by food deprivation in terms of antagonism by anorectic drugs and of anatomical site of action. Glucoprivic feeding was completely blocked by microinjection of amphetamine, fenfluramine, and mazindol into the paraventricular nucleus of the hypothalamus (PVN). Deprivation-induced feeding was not blocked by amphetamine, fenfluramine, or mazindol microinjected into the PVN. Neither the feeding induced by 2-deoxyglucose nor its reversal by amphetamine were blocked by pretreatment with the β-adrenergic antagonist, propranolol. Amphetamine and fenfluramine blocked both glucoprivic- and deprivation-induced feeding when microinjected into the perifornical region of the lateral hypothalamus. These data suggest that food consumption induced by 2-deoxyglucose treatment can be antagonized by anorectic drugs acting at recognition sites present in several hypothalamic nuclei, while deprivation-induced feeding acts through different receptor mechanisms which may be specific to the perifornical region of the lateral hypothalamus.
AB - Feeding induced by 2-deoxyglucose was compared with feeding induced by food deprivation in terms of antagonism by anorectic drugs and of anatomical site of action. Glucoprivic feeding was completely blocked by microinjection of amphetamine, fenfluramine, and mazindol into the paraventricular nucleus of the hypothalamus (PVN). Deprivation-induced feeding was not blocked by amphetamine, fenfluramine, or mazindol microinjected into the PVN. Neither the feeding induced by 2-deoxyglucose nor its reversal by amphetamine were blocked by pretreatment with the β-adrenergic antagonist, propranolol. Amphetamine and fenfluramine blocked both glucoprivic- and deprivation-induced feeding when microinjected into the perifornical region of the lateral hypothalamus. These data suggest that food consumption induced by 2-deoxyglucose treatment can be antagonized by anorectic drugs acting at recognition sites present in several hypothalamic nuclei, while deprivation-induced feeding acts through different receptor mechanisms which may be specific to the perifornical region of the lateral hypothalamus.
KW - 2-Deoxy-D-glucose
KW - Amphetamine
KW - Anorectic drugs
KW - Glucoprivic feeding
KW - Hypothalamus
KW - Paraventricular hypothalamic nucleus
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U2 - 10.1016/0091-3057(87)90572-7
DO - 10.1016/0091-3057(87)90572-7
M3 - Article
VL - 27
SP - 291
EP - 297
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 2
ER -