Sister chromatid exchange and gene mutation

A. V. Carrano, L. H. Thompson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The parallel induction of sister chromatid exchange (SCE) and single-gene mutation was quantified in Chinese hamster ovary cells following exposure to nine different physical or chemical agents representing a wide variety of inducing lesions. For each agent, the frequency of induced SCE was linearly related to the induction of mutation, but the efficiency of SCE formation relative to mutation induction differed for each. Studies in repair deficient cells suggested that unrepaired lesions enhanced the induction of both SCE and mutation but that the degree of enhancement was not necessarily the same for both endpoints.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalCytogenetics and Cell Genetics
Issue number1-2
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Genetics


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