Sirtuins in dermatology: Applications for future research and therapeutics

Melissa Serravallo, Jared Jagdeo, Sharon A. Glick, Daniel M. Siegel, Neil I. Brody

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Sirtuins are a family of seven proteins in humans (SIRT1-SIRT7) that are involved in multiple cellular processes relevant to dermatology. The role of sirtuins in other organ systems is established. However, the importance of these proteins in dermatology is less defined. Recently, sirtuins gained international attention because of their role as "longevity proteins" that may extend and enhance human life. Sirtuins function in the cell via histone deacetylase and/or adenosine diphosphate ribosyltransferase enzymatic activity that target histone and non-histone substrates, including transcription regulators, tumor suppressors, structural proteins, DNA repair proteins, cell signaling proteins, transport proteins, and enzymes. Sirtuins are involved in cellular pathways related to skin structure and function, including aging, ultraviolet-induced photoaging, inflammation, epigenetics, cancer, and a variety of cellular functions including cell cycle, DNA repair and proliferation. This review highlights sirtuin-related cellular pathways, therapeutics and pharmacological targets in atopic dermatitis, bullous dermatoses, collagen vascular disorders, psoriasis, systemic lupus erythematosus, hypertrophic and keloid scars, cutaneous infections, and non-melanoma and melanoma skin cancer. Also discussed is the role of sirtuins in the following genodermatoses: ataxia telangiectasia, Cowden's syndrome, dyskeratosis congenita, Rubenstein-Taybi, Werner syndrome, and xeroderma pigmentosum. The pathophysiology of these inherited diseases is not well understood, and sirtuin-related processes represent potential therapeutic targets for diseases lacking suitable alternative treatments. The goal of this review is to bring attention to the dermatology community, physicians, and scientists, the importance of sirtuins in dermatology and provide a foundation and impetus for future discussion, research and pharmacologic discovery.

Original languageEnglish (US)
Pages (from-to)269-282
Number of pages14
JournalArchives of Dermatological Research
Volume305
Issue number4
DOIs
StatePublished - May 2013

Fingerprint

Sirtuins
Therapeutic Human Experimentation
Dermatology
DNA Repair
Dyskeratosis Congenita
Multiple Hamartoma Syndrome
Vesiculobullous Skin Diseases
Werner Syndrome
Hypertrophic Cicatrix
Tumor Suppressor Proteins
Keloid
Xeroderma Pigmentosum
Ataxia Telangiectasia
Skin
Proteins
Histone Deacetylases
Skin Neoplasms
Protein Transport
Atopic Dermatitis
Psoriasis

Keywords

  • Aging
  • Dermatology
  • Genodermatoses
  • Inflammation
  • Sirtuins
  • Skin cancer

ASJC Scopus subject areas

  • Dermatology

Cite this

Sirtuins in dermatology : Applications for future research and therapeutics. / Serravallo, Melissa; Jagdeo, Jared; Glick, Sharon A.; Siegel, Daniel M.; Brody, Neil I.

In: Archives of Dermatological Research, Vol. 305, No. 4, 05.2013, p. 269-282.

Research output: Contribution to journalArticle

Serravallo, Melissa ; Jagdeo, Jared ; Glick, Sharon A. ; Siegel, Daniel M. ; Brody, Neil I. / Sirtuins in dermatology : Applications for future research and therapeutics. In: Archives of Dermatological Research. 2013 ; Vol. 305, No. 4. pp. 269-282.
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