Single shot retinal imaging with AO spectral OCT

Yan Zhang, Jungtae Rha, Ravi Jonnal, Donald T. Miller

Research output: Contribution to journalConference article

3 Scopus citations

Abstract

We demonstrate for the first time an adaptive optics (AO) spectral OCT retina camera that acquires with unprecedented 3D resolution (2.9 μm lateral; 5.5 μm axial) single shot B-scans of the living human retina. The camera centers on a Michelson interferometer that consists of a superluminescent diode for line illuminating the subject's retinal; voice coil translator for controlling the optical path length of the reference channel; and an imaging spectrometer that is cascaded with a 12-bit area CCD array. The imaging spectrometer was designed with negligible off-axis aberrations and was constructed from stock optical components. AO was integrated into the detector channel of the interferometer and dynamically compensated for most of the ocular aberration across a 6 mm pupil. Short bursts of B-scans, with 100 A-scans each, were successfully acquired at 1 msec intervals. Camera sensitivity was found sufficient to detect reflections from all major retinal layers. Individual outer segments of photoreceptors at different retinal eccentricities were observed in vivo. Periodicity of the outer segments matched cone spacing as measured from AO flood illuminated images of the same patches of retina.

Original languageEnglish (US)
Article number95
Pages (from-to)548-555
Number of pages8
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5690
DOIs
StatePublished - Jul 21 2005
Externally publishedYes
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

Keywords

  • Adaptive optics
  • Eye
  • Optical coherence tomography
  • Photoreceptors
  • Retina
  • Spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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