Single pathogen challenge with agents of the bovine respiratory disease complex

Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Bovine respiratory disease complex (BRDC) is an important cause of mortality and morbidity in cattle; costing the dairy and beef industries millions of dollars annually, despite the use of vaccines and antibiotics. BRDC is caused by one or more of several viruses (bovine respiratory syncytial virus, bovine herpes type 1 also known as infectious bovine rhinotracheitis, and bovine viral diarrhea virus), which predispose animals to infection with one or more bacteria. These include: Pasteurella multocida, Mannheimia haemolytica, Mycoplasma bovis, and Histophilus somni. Some cattle appear to be more resistant to BRDC than others.We hypothesize that appropriate immune responses to these pathogens are subject to genetic control. To determine which genes are involved in the immune response to each of these pathogens it was first necessary to experimentally induce infection separately with each pathogen to document clinical and pathological responses in animals from which tissues were harvested for subsequent RNA sequencing. Herein these infections and animal responses are described.

Original languageEnglish (US)
Article numbere0142479
JournalPLoS One
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2015

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Bovine Respiratory Disease Complex
bovine respiratory disease
Pulmonary diseases
Pathogens
Viruses
Animals
animal behavior
pathogens
cattle
Dairying
Pasteurellaceae
Mycoplasma bovis
Infectious Bovine Rhinotracheitis
Bovine respiratory syncytial virus
Infection
immune response
infection
Mannheimia haemolytica
RNA Sequence Analysis
Bovine Viral Diarrhea Viruses

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team (2015). Single pathogen challenge with agents of the bovine respiratory disease complex. PLoS One, 10(11), [e0142479]. https://doi.org/10.1371/journal.pone.0142479

Single pathogen challenge with agents of the bovine respiratory disease complex. / Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team.

In: PLoS One, Vol. 10, No. 11, e0142479, 01.11.2015.

Research output: Contribution to journalArticle

Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team 2015, 'Single pathogen challenge with agents of the bovine respiratory disease complex', PLoS One, vol. 10, no. 11, e0142479. https://doi.org/10.1371/journal.pone.0142479
Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team. Single pathogen challenge with agents of the bovine respiratory disease complex. PLoS One. 2015 Nov 1;10(11). e0142479. https://doi.org/10.1371/journal.pone.0142479
Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team. / Single pathogen challenge with agents of the bovine respiratory disease complex. In: PLoS One. 2015 ; Vol. 10, No. 11.
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