Single and multiple exposure tolerance study of cellulose sulfate gel: A Phase I safety and colposcopy study

Christine Mauck, Debra H. Weiner, Susan Ballagh, Mitchell D Creinin, David F. Archer, Jill Schwartz, Helen Pymar, Jaim Jou Lai, Marianne Callahan

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Vaginally applied gels offer a promising approach for preventing unwanted pregnancies and sexually transmitted infections. Cellulose sulfate (CS) is a non-cytotoxic antifertility agent that also exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV. This was a randomized, double-blinded, Phase I study of 2.5 mL and 5.0 mL doses of 6% CS gel. A single vaginal application of the gel followed by five consecutive daily doses was assessed for genital irritation, safety, vaginal leakage, and product acceptability compared to two controls, Conceptrol, which is a marketed contraceptive gel containing nonoxynol-9, and K-Y jelly. The results suggest that the safety of 6% CS was comparable to that of Conceptrol and K-Y jelly, and it may be associated with less genital irritation. The 2.5 mL dose of CS may be preferable according to the participants' reports of leakage. All the products had similar acceptability profiles.

Original languageEnglish (US)
Pages (from-to)383-391
Number of pages9
JournalContraception
Volume64
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Cellulose sulfate
  • Contraception
  • Female
  • Microbicide
  • Phase I clinical trial
  • Sexually transmitted diseases
  • Spermicide
  • Vaginal
  • Vaginal irritation

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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  • Cite this

    Mauck, C., Weiner, D. H., Ballagh, S., Creinin, M. D., Archer, D. F., Schwartz, J., Pymar, H., Lai, J. J., & Callahan, M. (2001). Single and multiple exposure tolerance study of cellulose sulfate gel: A Phase I safety and colposcopy study. Contraception, 64(6), 383-391. https://doi.org/10.1016/S0010-7824(01)00271-2