Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis

Sun Yinghua, Liu Rui, Daniel S. Elson, Christopher W. Hollars, Javier A. Jo, Park Jesung, Sun Yang, Laura Marcu

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A novel fiber-optic-based method for simultaneous time- and wavelength-resolved fluorescence spectroscopy for the rapid diagnosis of diseased tissue is demonstrated. By combining multiple bandpass and dichroic filters (405/40, 460/50, and 550/50) with different lengths of optical fiber (1, 10, and 19 m) acting as an optical delay this system enables the near real-time acquisition and characterization of time-resolved fluorescence spectra using a single detector and excitation input. The recording of multiple fluorescence response pulses at selected wavelengths can be completed in hundreds of nanoseconds, which provides the capability of a real-time characterization of biological systems.

Original languageEnglish (US)
Pages (from-to)630-632
Number of pages3
JournalOptics Letters
Volume33
Issue number6
DOIs
StatePublished - Mar 15 2008

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Yinghua, S., Rui, L., Elson, D. S., Hollars, C. W., Jo, J. A., Jesung, P., Yang, S., & Marcu, L. (2008). Simultaneous time- and wavelength-resolved fluorescence spectroscopy for near real-time tissue diagnosis. Optics Letters, 33(6), 630-632. https://doi.org/10.1364/OL.33.000630