Abstract
A novel fiber-optic-based method for simultaneous time- and wavelength-resolved fluorescence spectroscopy for the rapid diagnosis of diseased tissue is demonstrated. By combining multiple bandpass and dichroic filters (405/40, 460/50, and 550/50) with different lengths of optical fiber (1, 10, and 19 m) acting as an optical delay this system enables the near real-time acquisition and characterization of time-resolved fluorescence spectra using a single detector and excitation input. The recording of multiple fluorescence response pulses at selected wavelengths can be completed in hundreds of nanoseconds, which provides the capability of a real-time characterization of biological systems.
Original language | English (US) |
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Pages (from-to) | 630-632 |
Number of pages | 3 |
Journal | Optics Letters |
Volume | 33 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2008 |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics