Simultaneous phase-contrast MRI and PET for noninvasive quantification of cerebral blood flow and reactivity in healthy subjects and patients with cerebrovascular disease

Yosuke Ishii, Thoralf Thamm, Jia Guo, Mohammad Mehdi Khalighi, Mirwais Wardak, Dawn Holley, Harsh Gandhi, Jun Hyung Park, Bin Shen, Gary K. Steinberg, Frederick T. Chin, Greg Zaharchuk, Audrey Peiwen Fan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: H2 15O-positron emission tomography (PET) is considered the reference standard for absolute cerebral blood flow (CBF). However, this technique requires an arterial input function measured through continuous sampling of arterial blood, which is invasive and has limitations with tracer delay and dispersion. Purpose: To demonstrate a new noninvasive method to quantify absolute CBF with a PET/MRI hybrid scanner. This blood-free approach, called PC-PET, takes the spatial CBF distribution from a static H2 15O-PET scan, and scales it to the whole-brain average CBF value measured by simultaneous phase-contrast MRI. Study Type: Observational. Subjects: Twelve healthy controls (HC) and 13 patients with Moyamoya disease (MM) as a model of chronic ischemic disease. Field Strength/Sequences: 3T/2D cardiac-gated phase-contrast MRI and H2 15O-PET. Assessment: PC-PET CBF values from whole brain (WB), gray matter (GM), and white matter (WM) in HCs were compared with literature values since 2000. CBF and cerebrovascular reactivity (CVR), which is defined as the percent CBF change between baseline and post-acetazolamide (vasodilator) scans, were measured by PC-PET in MM patients and HCs within cortical regions corresponding to major vascular territories. Statistical Tests: Linear, mixed effects models were created to compare CBF and CVR, respectively, between patients and controls, and between different degrees of stenosis. Results: The mean CBF values in WB, GM, and WM in HC were 42 ± 7 ml/100 g/min, 50 ± 7 ml/100 g/min, and 23 ± 3 ml/100 g/min, respectively, which agree well with literature values. Compared with normal regions (57 ± 23%), patients showed significantly decreased CVR in areas with mild/moderate stenosis (47 ± 17%, P = 0.011) and in severe/occluded areas (40 ± 16%, P = 0.016). Data Conclusion: PC-PET identifies differences in cerebrovascular reactivity between healthy controls and cerebrovascular patients. PC-PET is suitable for CBF measurement when arterial blood sampling is not accessible, and warrants comparison to fully quantitative H2 15O-PET in future studies. Level of Evidence: 3. Technical Efficacy Stage: 2. J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;51:183–194.

Original languageEnglish (US)
Pages (from-to)183-194
Number of pages12
JournalJournal of Magnetic Resonance Imaging
Volume51
Issue number1
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • cerebral blood flow
  • cerebrovascular reactivity
  • moyamoya disease
  • perfusion imaging
  • phase-contrast MRI
  • positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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