Simultaneous PET-MRI: A new approach for functional and morphological imaging

Martin S. Judenhofer; Hans F. Wehrl; Danny F. Newport; Ciprian Catana; Stefan B. Siegel; Markus Becker; Axel Thielscher; Manfred Kneilling; Matthias P. Lichy; Martin Eichner; Karin Klingel; Gerald Reischl; Stefan Widmaier; Martin Röcken; Robert E. Nutt; Hans Jürgen Machulla; Kamil Uludag; Simon R Cherry; Claus D. Claussen; Bernd J. Pichler

doi:10.1038/nm1700

Simultaneous PET-MRI: A new approach for functional and morphological imaging

Martin S. Judenhofer, Hans F. Wehrl, Danny F. Newport, Ciprian Catana, Stefan B. Siegel, Markus Becker, Axel Thielscher, Manfred Kneilling, Matthias P. Lichy, Martin Eichner, Karin Klingel, Gerald Reischl, Stefan Widmaier, Martin Röcken, Robert E. Nutt, Hans Jürgen Machulla, Kamil Uludag, Simon R Cherry, Claus D. Claussen, Bernd J. Pichler

Radiology

Research output: Contribution to journal › Article › peer-review

713 Scopus citations

Abstract

Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft-tissue contrast and provides spectroscopic information and functional MRI (fMRI). We have developed a three-dimensional animal PET scanner that is built into a 7-T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET-MRI data from living mice. PET-MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.

Original language	English (US)
Pages (from-to)	459-465
Number of pages	7
Journal	Nature Medicine
Volume	14
Issue number	4
DOIs	https://doi.org/10.1038/nm1700
State	Published - Apr 2008

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Judenhofer, M. S., Wehrl, H. F., Newport, D. F., Catana, C., Siegel, S. B., Becker, M., Thielscher, A., Kneilling, M., Lichy, M. P., Eichner, M., Klingel, K., Reischl, G., Widmaier, S., Röcken, M., Nutt, R. E., Machulla, H. J., Uludag, K., Cherry, S. R., Claussen, C. D., & Pichler, B. J. (2008). Simultaneous PET-MRI: A new approach for functional and morphological imaging. Nature Medicine, 14(4), 459-465. https://doi.org/10.1038/nm1700

Simultaneous PET-MRI : A new approach for functional and morphological imaging. / Judenhofer, Martin S.; Wehrl, Hans F.; Newport, Danny F.; Catana, Ciprian; Siegel, Stefan B.; Becker, Markus; Thielscher, Axel; Kneilling, Manfred; Lichy, Matthias P.; Eichner, Martin; Klingel, Karin; Reischl, Gerald; Widmaier, Stefan; Röcken, Martin; Nutt, Robert E.; Machulla, Hans Jürgen; Uludag, Kamil; Cherry, Simon R; Claussen, Claus D.; Pichler, Bernd J.

In: Nature Medicine, Vol. 14, No. 4, 04.2008, p. 459-465.

Research output: Contribution to journal › Article › peer-review

Judenhofer, MS, Wehrl, HF, Newport, DF, Catana, C, Siegel, SB, Becker, M, Thielscher, A, Kneilling, M, Lichy, MP, Eichner, M, Klingel, K, Reischl, G, Widmaier, S, Röcken, M, Nutt, RE, Machulla, HJ, Uludag, K, Cherry, SR, Claussen, CD & Pichler, BJ 2008, 'Simultaneous PET-MRI: A new approach for functional and morphological imaging', Nature Medicine, vol. 14, no. 4, pp. 459-465. https://doi.org/10.1038/nm1700

Judenhofer, Martin S. ; Wehrl, Hans F. ; Newport, Danny F. ; Catana, Ciprian ; Siegel, Stefan B. ; Becker, Markus ; Thielscher, Axel ; Kneilling, Manfred ; Lichy, Matthias P. ; Eichner, Martin ; Klingel, Karin ; Reischl, Gerald ; Widmaier, Stefan ; Röcken, Martin ; Nutt, Robert E. ; Machulla, Hans Jürgen ; Uludag, Kamil ; Cherry, Simon R ; Claussen, Claus D. ; Pichler, Bernd J. / Simultaneous PET-MRI : A new approach for functional and morphological imaging. In: Nature Medicine. 2008 ; Vol. 14, No. 4. pp. 459-465.

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