Abstract
Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft-tissue contrast and provides spectroscopic information and functional MRI (fMRI). We have developed a three-dimensional animal PET scanner that is built into a 7-T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET-MRI data from living mice. PET-MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 459-465 |
| Number of pages | 7 |
| Journal | Nature Medicine |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2008 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Simultaneous PET-MRI : A new approach for functional and morphological imaging. / Judenhofer, Martin S.; Wehrl, Hans F.; Newport, Danny F.; Catana, Ciprian; Siegel, Stefan B.; Becker, Markus; Thielscher, Axel; Kneilling, Manfred; Lichy, Matthias P.; Eichner, Martin; Klingel, Karin; Reischl, Gerald; Widmaier, Stefan; Röcken, Martin; Nutt, Robert E.; Machulla, Hans Jürgen; Uludag, Kamil; Cherry, Simon R; Claussen, Claus D.; Pichler, Bernd J.
In: Nature Medicine, Vol. 14, No. 4, 04.2008, p. 459-465.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simultaneous PET-MRI
T2 - A new approach for functional and morphological imaging
AU - Judenhofer, Martin S.
AU - Wehrl, Hans F.
AU - Newport, Danny F.
AU - Catana, Ciprian
AU - Siegel, Stefan B.
AU - Becker, Markus
AU - Thielscher, Axel
AU - Kneilling, Manfred
AU - Lichy, Matthias P.
AU - Eichner, Martin
AU - Klingel, Karin
AU - Reischl, Gerald
AU - Widmaier, Stefan
AU - Röcken, Martin
AU - Nutt, Robert E.
AU - Machulla, Hans Jürgen
AU - Uludag, Kamil
AU - Cherry, Simon R
AU - Claussen, Claus D.
AU - Pichler, Bernd J.
PY - 2008/4
Y1 - 2008/4
N2 - Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft-tissue contrast and provides spectroscopic information and functional MRI (fMRI). We have developed a three-dimensional animal PET scanner that is built into a 7-T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET-MRI data from living mice. PET-MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.
AB - Noninvasive imaging at the molecular level is an emerging field in biomedical research. This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI). Although the value of PET lies in its high-sensitivity tracking of biomarkers in vivo, it lacks resolving morphology. MRI has lower sensitivity, but produces high soft-tissue contrast and provides spectroscopic information and functional MRI (fMRI). We have developed a three-dimensional animal PET scanner that is built into a 7-T MRI. Our evaluations show that both modalities preserve their functionality, even when operated isochronously. With this combined imaging system, we simultaneously acquired functional and morphological PET-MRI data from living mice. PET-MRI provides a powerful tool for studying biology and pathology in preclinical research and has great potential for clinical applications. Combining fMRI and spectroscopy with PET paves the way for a new perspective in molecular imaging.
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UR - http://www.scopus.com/inward/citedby.url?scp=41849093686&partnerID=8YFLogxK
U2 - 10.1038/nm1700
DO - 10.1038/nm1700
M3 - Article
C2 - 18376410
AN - SCOPUS:41849093686
VL - 14
SP - 459
EP - 465
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 4
ER -