Simultaneous optical and acoustical observations of contrast agents

P. Dayton, K. Morgan, M. Allietta, A. Klibanov, G. Brandenburger, K. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Scopus citations


The increasing interest in the use of encapsulated microbubbles for ultrasound contrast agents and drug delivery mechanisms requires an understanding of the insonified microbubble on a microscopic scale. With the use of a video microscopy system coupled to either a microscopic ultrasound flow phantom or a chamber for insonifying stationary bubbles, we show that ultrasound has significant effects on encapsulated microbubbles. A train of ultrasound pulses can alter the structure of an albumin-shelled bubble or instigate various mechanisms of bubble destruction. Ultrasonic transmission also produces a primary radiation force which can displace contrast agents with each acoustic pulse, and we demonstrate this in-vivo as well as in-vitro. Secondary radiation force is shown to cause changes in effective scatterer size, echo characteristics, and persistence.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsS.C. Schneider, M. Levy, B.R. McAvoy
Number of pages9
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 IEEE Ultrasonics Symposium. Part 1 (of 2) - Toronto, Can
Duration: Oct 5 1997Oct 8 1997


OtherProceedings of the 1997 IEEE Ultrasonics Symposium. Part 1 (of 2)
CityToronto, Can

ASJC Scopus subject areas

  • Engineering(all)


Dive into the research topics of 'Simultaneous optical and acoustical observations of contrast agents'. Together they form a unique fingerprint.

Cite this