Abstract
The increasing interest in the use of encapsulated microbubbles for ultrasound contrast agents and drug delivery mechanisms requires an understanding of the insonified microbubble on a microscopic scale. With the use of a video microscopy system coupled to either a microscopic ultrasound flow phantom or a chamber for insonifying stationary bubbles, we show that ultrasound has significant effects on encapsulated microbubbles. A train of ultrasound pulses can alter the structure of an albumin-shelled bubble or instigate various mechanisms of bubble destruction. Ultrasonic transmission also produces a primary radiation force which can displace contrast agents with each acoustic pulse, and we demonstrate this in-vivo as well as in-vitro. Secondary radiation force is shown to cause changes in effective scatterer size, echo characteristics, and persistence.
Original language | English (US) |
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Title of host publication | Proceedings of the IEEE Ultrasonics Symposium |
Editors | S.C. Schneider, M. Levy, B.R. McAvoy |
Publisher | IEEE |
Pages | 1583-1591 |
Number of pages | 9 |
Volume | 2 |
State | Published - 1997 |
Externally published | Yes |
Event | Proceedings of the 1997 IEEE Ultrasonics Symposium. Part 1 (of 2) - Toronto, Can Duration: Oct 5 1997 → Oct 8 1997 |
Other
Other | Proceedings of the 1997 IEEE Ultrasonics Symposium. Part 1 (of 2) |
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City | Toronto, Can |
Period | 10/5/97 → 10/8/97 |
ASJC Scopus subject areas
- Engineering(all)