Simultaneous molecular and anatomical imaging of the mouse in vivo

Andrew L. Goertzen, A. Ken Meadors, Robert W. Silverman, Simon R Cherry

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Non-invasive imaging technologies are opening up new windows into mouse biology. We have developed a mouse imaging system that integrates positron emission tomography (PET) with x-ray computed tomography (CT), allowing simultaneous anatomic and molecular imaging in vivo with the potential for precise registration of the two image volumes. The x-ray system consists of a compact mini-focal x-ray tube and an amorphous selenium flat panel x-ray detector with a low-noise CMOS readout. The PET system uses planar arrays of lutetium oxyorthosilicate scintillator coupled to position-sensitive photomultiplier tubes. We describe the design of this dual-modality imaging system and show, for the first time, simultaneously acquired PET and CT images in a phantom and in mice.

Original languageEnglish (US)
Pages (from-to)4315-4328
Number of pages14
JournalPhysics in Medicine and Biology
Volume47
Issue number24
DOIs
StatePublished - Dec 21 2002

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ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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