Abstract
We present a novel fiber-based imaging platform that allows simultaneous fluorescence lifetime imaging (FLIm) and optical coherence tomography (OCT) using a double-clad fiber. This platform acquires co-registered images showing structural and compositional contrast in unlabeled biological samples by scanning the fiber tip across the sample surface. In this Letter, we report a characterization of each modality and show examples of co-registered FLIm and OCT images acquired from a lemon segment and a section of human coronary artery. The close comparison between the combined FLIm and OCT images and a co-registered histology section provides a qualitative validation of the technique and highlights its potential for minimally invasive, multimodal imaging of tissue structure and composition.
Original language | English (US) |
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Pages (from-to) | 3753-3756 |
Number of pages | 4 |
Journal | Optics Letters |
Volume | 42 |
Issue number | 19 |
DOIs | |
State | Published - Oct 1 2017 |
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics