Simultaneous correction of the influence of skin color and fat on tissue spectroscopy by use of a two-distance fiber-optic probe and orthogonalization technique

Ye Yang, Michelle R. Landry, Olusola O. Soyemi, Michael A. Shear, Dulce S. Anunciacion, Babs R. Soller

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We have demonstrated simultaneous correction for the optical interference of skin and fat in tissue spectra by using a two-distance fiber-optic probe. We obtained the correction by orthogonalizing the spectra collected at a long source-detector distance (SD) to the spectra collected at a short SD and mapped to the long SD space. The method was validated in tissuelike three-layer phantoms as well as preliminarily in human tissue. After the correction, a partial-least-squares model of the phantoms showed enhanced prediction performance.

Original languageEnglish (US)
Pages (from-to)2269-2271
Number of pages3
JournalOptics Letters
Volume30
Issue number17
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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