Simulation of the thermoregulatory system of rats exposed concurrently to cold and to acceleration fields

J. L. Giacchino; J. M. Horowitz; Barbara A Horwitz

doi:10.1016/0010-4825(79)90005-2

Simulation of the thermoregulatory system of rats exposed concurrently to cold and to acceleration fields

J. L. Giacchino, J. M. Horowitz, Barbara A Horwitz

Physiology and Membrane Biology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A CSMP model has been developed that describes the thermoregulatory response of cold-exposed rats to acceleration fields of 1 to 5g. Experiments were designed to determine the temporal period over which the model accounts for responses of animals to concurrent cold and gravitational stressors. During the first hour following the onset of hypergravity, the model is not applicable since it includes no factors for regulation of peripheral blood flow. However, one hour after the onset of hypergravity, the model is appropriate since the thermoregulatory response that occurs is via graded control of shivering and nonshivering thermogenesis.

Original language	English (US)
Pages (from-to)	205-211
Number of pages	7
Journal	Computers in Biology and Medicine
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/0010-4825(79)90005-2
State	Published - 1979

Keywords

Computer simulation
Hypergravity
Neural model
Stress
Temperature regulation

ASJC Scopus subject areas

Computer Science Applications

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10.1016/0010-4825(79)90005-2

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abstract = "A CSMP model has been developed that describes the thermoregulatory response of cold-exposed rats to acceleration fields of 1 to 5g. Experiments were designed to determine the temporal period over which the model accounts for responses of animals to concurrent cold and gravitational stressors. During the first hour following the onset of hypergravity, the model is not applicable since it includes no factors for regulation of peripheral blood flow. However, one hour after the onset of hypergravity, the model is appropriate since the thermoregulatory response that occurs is via graded control of shivering and nonshivering thermogenesis.",

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AU - Horowitz, J. M.

AU - Horwitz, Barbara A

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N2 - A CSMP model has been developed that describes the thermoregulatory response of cold-exposed rats to acceleration fields of 1 to 5g. Experiments were designed to determine the temporal period over which the model accounts for responses of animals to concurrent cold and gravitational stressors. During the first hour following the onset of hypergravity, the model is not applicable since it includes no factors for regulation of peripheral blood flow. However, one hour after the onset of hypergravity, the model is appropriate since the thermoregulatory response that occurs is via graded control of shivering and nonshivering thermogenesis.

AB - A CSMP model has been developed that describes the thermoregulatory response of cold-exposed rats to acceleration fields of 1 to 5g. Experiments were designed to determine the temporal period over which the model accounts for responses of animals to concurrent cold and gravitational stressors. During the first hour following the onset of hypergravity, the model is not applicable since it includes no factors for regulation of peripheral blood flow. However, one hour after the onset of hypergravity, the model is appropriate since the thermoregulatory response that occurs is via graded control of shivering and nonshivering thermogenesis.

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KW - Hypergravity

KW - Neural model

KW - Stress

KW - Temperature regulation

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