Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array

Chun Yen Lai; Dustin E. Kruse; Douglas N. Stephens; Patrick L. Sutcliffe; Katherine W. Ferrara

doi:10.1109/ULTSYM.2010.5935922

Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array

Chun Yen Lai, Dustin E. Kruse, Douglas N. Stephens, Patrick L. Sutcliffe, Katherine W. Ferrara

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.

Original language	English (US)
Title of host publication	Proceedings - IEEE Ultrasonics Symposium
Pages	2270-2273
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2010.5935922
State	Published - 2010
Event	2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States Duration: Oct 11 2010 → Oct 14 2010

Other

Other	2010 IEEE International Ultrasonics Symposium, IUS 2010
Country	United States
City	San Diego, CA
Period	10/11/10 → 10/14/10

Keywords

finite-difference time-domain
Mild hyperthermia
temperature simulation

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2010.5935922

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Cite this

Lai, C. Y., Kruse, D. E., Stephens, D. N., Sutcliffe, P. L., & Ferrara, K. W. (2010). Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array. In Proceedings - IEEE Ultrasonics Symposium (pp. 2270-2273). [5935922] https://doi.org/10.1109/ULTSYM.2010.5935922

Lai, CY, Kruse, DE, Stephens, DN, Sutcliffe, PL & Ferrara, KW 2010, Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array. in Proceedings - IEEE Ultrasonics Symposium., 5935922, pp. 2270-2273, 2010 IEEE International Ultrasonics Symposium, IUS 2010, San Diego, CA, United States, 10/11/10. https://doi.org/10.1109/ULTSYM.2010.5935922

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keywords = "finite-difference time-domain, Mild hyperthermia, temperature simulation",

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AB - The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.

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