Abstract
The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.
Original language | English (US) |
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Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
Pages | 2270-2273 |
Number of pages | 4 |
DOIs | |
State | Published - 2010 |
Event | 2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States Duration: Oct 11 2010 → Oct 14 2010 |
Other
Other | 2010 IEEE International Ultrasonics Symposium, IUS 2010 |
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Country | United States |
City | San Diego, CA |
Period | 10/11/10 → 10/14/10 |
Keywords
- finite-difference time-domain
- Mild hyperthermia
- temperature simulation
ASJC Scopus subject areas
- Acoustics and Ultrasonics