Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array

Chun Yen Lai; Dustin E. Kruse; Douglas N. Stephens; Patrick L. Sutcliffe; Katherine W. Ferrara

doi:10.1109/ULTSYM.2010.5935922

Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array

Chun Yen Lai, Dustin E. Kruse, Douglas N. Stephens, Patrick L. Sutcliffe, Katherine W. Ferrara

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.

Original language	English (US)
Title of host publication	Proceedings - IEEE Ultrasonics Symposium
Pages	2270-2273
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2010.5935922
State	Published - 2010
Event	2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States Duration: Oct 11 2010 → Oct 14 2010

Other

Other	2010 IEEE International Ultrasonics Symposium, IUS 2010
Country	United States
City	San Diego, CA
Period	10/11/10 → 10/14/10

Keywords

finite-difference time-domain
Mild hyperthermia
temperature simulation

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2010.5935922

Fingerprint Dive into the research topics of 'Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array'. Together they form a unique fingerprint.

Cite this

Lai, CY, Kruse, DE, Stephens, DN, Sutcliffe, PL & Ferrara, KW 2010, Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array. in Proceedings - IEEE Ultrasonics Symposium., 5935922, pp. 2270-2273, 2010 IEEE International Ultrasonics Symposium, IUS 2010, San Diego, CA, United States, 10/11/10. https://doi.org/10.1109/ULTSYM.2010.5935922

@inproceedings{d069222f2c2f43c3bf50e3802c06f555,

title = "Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array",

abstract = "The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.",

keywords = "finite-difference time-domain, Mild hyperthermia, temperature simulation",

author = "Lai, {Chun Yen} and Kruse, {Dustin E.} and Stephens, {Douglas N.} and Sutcliffe, {Patrick L.} and Ferrara, {Katherine W.}",

year = "2010",

doi = "10.1109/ULTSYM.2010.5935922",

language = "English (US)",

isbn = "9781457703829",

pages = "2270--2273",

booktitle = "Proceedings - IEEE Ultrasonics Symposium",

note = "2010 IEEE International Ultrasonics Symposium, IUS 2010 ; Conference date: 11-10-2010 Through 14-10-2010",

}

TY - GEN

T1 - Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array

AU - Lai, Chun Yen

AU - Kruse, Dustin E.

AU - Stephens, Douglas N.

AU - Sutcliffe, Patrick L.

AU - Ferrara, Katherine W.

PY - 2010

Y1 - 2010

N2 - The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.

AB - The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.

KW - finite-difference time-domain

KW - Mild hyperthermia

KW - temperature simulation

UR - http://www.scopus.com/inward/record.url?scp=80054066170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054066170&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2010.5935922

DO - 10.1109/ULTSYM.2010.5935922

M3 - Conference contribution

AN - SCOPUS:80054066170

SN - 9781457703829

SP - 2270

EP - 2273

BT - Proceedings - IEEE Ultrasonics Symposium

T2 - 2010 IEEE International Ultrasonics Symposium, IUS 2010

Y2 - 11 October 2010 through 14 October 2010

ER -