Simulation and phantom validation of mild hyperthermia produced by a dualfunction ultrasound linear array

Chun Yen Lai, Dustin E. Kruse, Douglas N. Stephens, Patrick L. Sutcliffe, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


The prediction of the acoustic and temperature profiles is important forparameter optimization as a part of treatment planning for mild hyperthermia. A3D acoustic field algorithm and a finite-difference time-domain (FDTD) methodwere combined in this study to calculate a 3D temperature profile in atissue-mimicking phantom insonified by a dual function ultrasound linear array.In vitro validation was accomplished by using a fluorescent dye encapsulated inthermally-sensitive liposomes and an optical imaging system. For the single-beaminsonation mode, the 39°C contour (by simulation) and dye-release area (invitro) were 7.0 by 4.5 mm and 7.6 by 6.7 mm in the elevation and lateraldirections, respectively. For the scanned-beam insonation mode, the 39C contourand dye-release area were 12.0 by 11.4 mm and 12.2 by 11.6 mm in the elevationand lateral directions, respectively. The scanned-beam insonation mode showed asimilar spatial extent of heating between simulation and in vitro experiments.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Number of pages4
StatePublished - 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010


Other2010 IEEE International Ultrasonics Symposium, IUS 2010
Country/TerritoryUnited States
CitySan Diego, CA


  • finite-difference time-domain
  • Mild hyperthermia
  • temperature simulation

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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