Similarities in circuitry between Ammon's horn and dentate gyrus

Local interactions and parallel processing

Philip A Schwartzkroin, H. E. Scharfman, R. S. Sloviter

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

We present a 'model' of hippocampal information processing based on a review of recent data regarding the local circuitry of Ammon's horn and the dentate gyrus. We have been struck by the parallels in cell type and connectivity in Ammon's horn and the dentate gyrus, and have focused on similarities between CA3 pyramidal cells and mossy cells. Important conclusions of our analysis include the following: (1) The idea of serial processing of afferent information, from one hippocampal subregion to the next, is inadequate and based on an over-simplification of circuitry; information processing undoubtedly occurs over parallel, as well as serial, pathways. (2) Local circuitry within a given hippocampal subregion gives rise predominantly to feedforward inhbition; recurrent inhibition is present, but less potent. (3) There are multiple populations of local circuit neurons, each of which has a specific function, characteristic interconnections, and special cell properties. It is misleading to categorize these cells into a single category of inhibitory interneuron.

Original languageEnglish (US)
Pages (from-to)269-286
Number of pages18
JournalProgress in Brain Research
Volume83
StatePublished - 1990
Externally publishedYes

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Dentate Gyrus
Hippocampus
Automatic Data Processing
Pyramidal Cells
Interneurons
Neurons
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Similarities in circuitry between Ammon's horn and dentate gyrus : Local interactions and parallel processing. / Schwartzkroin, Philip A; Scharfman, H. E.; Sloviter, R. S.

In: Progress in Brain Research, Vol. 83, 1990, p. 269-286.

Research output: Contribution to journalArticle

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