Similar long-term outcomes for laparoscopic versus open live-donor nephrectomy kidney grafts: An OPTN database analysis of 5532 adult recipients

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Abstract

Prior studies that included both adult and pediatric recipients suggested slower early graft function for laparoscopically (vs. openly) procured live donor kidney grafts (LD-Ktxs). Any potential long-term impact, however, remains unknown. We compared long-term outcomes of 2685 (49%) laparoscopic vs. 2847 (51%) open LD-Ktxs reported to the Organ Procurement and Transplantation Network performed in adult (≥18 yrs) recipients between November 1999 and December 2000, with follow-up to February 2006. Acute and chronic rejection accounted for 152 laparoscopic (51%) vs. 148 (46%) open graft losses (P=NS). At discharge and at 5 years, graft function was similar for both groups; graft survival at 5 years was 79% (laparoscopic) vs. 80% (open) (P=NS). We conclude that despite prior reports of slower early laparoscopic LD-Ktx function, both laparoscopic and open nephrectomy are equally effective for procurement of kidneys for adult recipients with regard to short- and long-term (>5 years) function and survival. Future studies must investigate whether these findings apply also to pediatric LD-Ktx recipients.

Original languageEnglish (US)
Pages (from-to)916-919
Number of pages4
JournalTransplantation
Volume85
Issue number6
DOIs
StatePublished - Mar 2008

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Nephrectomy
Databases
Transplants
Kidney
Pediatrics
Tissue and Organ Procurement
Organ Transplantation
Graft Survival

Keywords

  • Kidney graft survival
  • Kidney recipient outcome
  • Kidney transplantation
  • Laparoscopic nephrectomy
  • Live kidney donor
  • Surgical technique

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

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abstract = "Prior studies that included both adult and pediatric recipients suggested slower early graft function for laparoscopically (vs. openly) procured live donor kidney grafts (LD-Ktxs). Any potential long-term impact, however, remains unknown. We compared long-term outcomes of 2685 (49{\%}) laparoscopic vs. 2847 (51{\%}) open LD-Ktxs reported to the Organ Procurement and Transplantation Network performed in adult (≥18 yrs) recipients between November 1999 and December 2000, with follow-up to February 2006. Acute and chronic rejection accounted for 152 laparoscopic (51{\%}) vs. 148 (46{\%}) open graft losses (P=NS). At discharge and at 5 years, graft function was similar for both groups; graft survival at 5 years was 79{\%} (laparoscopic) vs. 80{\%} (open) (P=NS). We conclude that despite prior reports of slower early laparoscopic LD-Ktx function, both laparoscopic and open nephrectomy are equally effective for procurement of kidneys for adult recipients with regard to short- and long-term (>5 years) function and survival. Future studies must investigate whether these findings apply also to pediatric LD-Ktx recipients.",
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