Similar effects of zinc deficiency and restricted feeding on plasma lipids and lipoproteins in rats

B. O. Schneeman, D. Lacy, D. Ney, M. L. Lefevre, Carl L Keen, B. Lonnerdal, L. S. Hurley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The objective of this study was to determine whether alterations in HDL composition observed previously were due specifically to zinc deficiency or to reduction in food intake. Rats were placed into three groups and fed for 21 d a zinc-adequate diet (100 ppm) ad libitum, or a zinc-deficient diet (<1 ppm) ad libitum, or the zinc-adequate diet at an intake equal to that of the deficient group. Blood plasma was fractionated into VLDL, LDL and HDL fractions, and plasma and the isolated fractions were analyzed for lipids and apolipoprotein composition. Analysis of plasma and liver zinc indicated that animals consuming the low zinc diet were deficient. Zinc deficiency and restricted feeding were associated with lower plasma and VLDL triglyceride levels and lower HDL cholesterol levels. The similarities in overall pattern of lipoprotein composition between the zinc-deficient and restricted-intake groups indicate that reduction in food intake may account for the differences in lipoprotein composition which were observed.

Original languageEnglish (US)
Pages (from-to)1889-1895
Number of pages7
JournalJournal of Nutrition
Volume116
Issue number10
StatePublished - 1986

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restricted feeding
lipoproteins
blood lipids
Lipoproteins
Zinc
zinc
Lipids
rats
Diet
diet
food intake
Eating
apolipoproteins
Apolipoproteins
blood plasma
high density lipoprotein cholesterol
HDL Cholesterol
triacylglycerols
liver
Liver

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Schneeman, B. O., Lacy, D., Ney, D., Lefevre, M. L., Keen, C. L., Lonnerdal, B., & Hurley, L. S. (1986). Similar effects of zinc deficiency and restricted feeding on plasma lipids and lipoproteins in rats. Journal of Nutrition, 116(10), 1889-1895.

Similar effects of zinc deficiency and restricted feeding on plasma lipids and lipoproteins in rats. / Schneeman, B. O.; Lacy, D.; Ney, D.; Lefevre, M. L.; Keen, Carl L; Lonnerdal, B.; Hurley, L. S.

In: Journal of Nutrition, Vol. 116, No. 10, 1986, p. 1889-1895.

Research output: Contribution to journalArticle

Schneeman, BO, Lacy, D, Ney, D, Lefevre, ML, Keen, CL, Lonnerdal, B & Hurley, LS 1986, 'Similar effects of zinc deficiency and restricted feeding on plasma lipids and lipoproteins in rats', Journal of Nutrition, vol. 116, no. 10, pp. 1889-1895.
Schneeman BO, Lacy D, Ney D, Lefevre ML, Keen CL, Lonnerdal B et al. Similar effects of zinc deficiency and restricted feeding on plasma lipids and lipoproteins in rats. Journal of Nutrition. 1986;116(10):1889-1895.
Schneeman, B. O. ; Lacy, D. ; Ney, D. ; Lefevre, M. L. ; Keen, Carl L ; Lonnerdal, B. ; Hurley, L. S. / Similar effects of zinc deficiency and restricted feeding on plasma lipids and lipoproteins in rats. In: Journal of Nutrition. 1986 ; Vol. 116, No. 10. pp. 1889-1895.
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