Simian immunodeficiency virus-specific T-cell-mediated proliferative response of infected rhesus macaques

Thomas P. McGraw, Benjamin R. Vowels, Murray B. Gardner, Aftab Ahmed-Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

While cell-mediated immunity is known to play an important role in controlling viral infections, its role in human and experimental animal models of human AIDS has not been established. To address this issue, four juvenile rhesus macaques were infected with simian immunodeficiency virus SIVMAC. Freshly isolated peripheral blood mononuclear cells from these SIVMAC-infected macaques and four uninfected control macaques were assessed for T-cell proliferative activity to SIV, monthly, for 10 consecutive months. T cells from SIV-infected monkeys failed to proliferate in response to SIV added directly to the culture. However, when SIV was processed by autologous antigen-presenting cells prior to culture with purified T cells, proliferative responses were uniformly demonstrated in SIV-infected monkeys, but not in uninfected controls. Proliferation in response to heat-inactivated SIV was mediated by CD4+ T cells and was shown to be MHC class II-restricted. However, the proliferative response to infectious SIV was mediated by both CD44- and CD8+ T cells and was MHC class-restricted. As disease progressed, a decline in the T-cell proliferative response was observed.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalAIDS
Volume4
Issue number3
StatePublished - Mar 1990

Keywords

  • AIDS
  • Cell-mediated immunity
  • Simian immunodeficiency virus
  • T lymphocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    McGraw, T. P., Vowels, B. R., Gardner, M. B., Ahmed-Ansari, A., & Gershwin, M. E. (1990). Simian immunodeficiency virus-specific T-cell-mediated proliferative response of infected rhesus macaques. AIDS, 4(3), 191-198.