Simian immunodeficiency virus needlestick accident in a laboratory worker

R. F. Khabbaz, T. Rowe, W. M. Heneine, J. E. Kaplan, T. M. Folks, C. A. Schable, J. R. George, C. Pau, B. S. Parekh, J. W. Curran, G. Schochetman, Michael Dale Lairmore, M. Murphey-Corb

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42 Scopus citations

Abstract

The macaque monkey infected with simian immunodeficiency virus (SIV) is an animal model of the acquired immunodeficiency syndrome. We investigated a laboratory worker who was exposed by needlestick accident to blood from an SIV-infected macaque. Seroreactivity to SIV developed within 3 months of exposure, with antibody titres peaking from the third to the fifth month and declining thereafter. Polymerase chain reaction for SIV sequences and cultures of peripheral-blood mononuclear cells failed to show infection. Inoculation of an SIV-negative monkey with blood from the worker did not cause infection. Animal-care and laboratory workers should adhere strictly to recommended procedures to avoid accidental exposures when working with SIV-infected animals or specimens.

Original languageEnglish (US)
Pages (from-to)271-273
Number of pages3
JournalThe Lancet
Volume340
Issue number8814
DOIs
StatePublished - Aug 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Khabbaz, R. F., Rowe, T., Heneine, W. M., Kaplan, J. E., Folks, T. M., Schable, C. A., George, J. R., Pau, C., Parekh, B. S., Curran, J. W., Schochetman, G., Lairmore, M. D., & Murphey-Corb, M. (1992). Simian immunodeficiency virus needlestick accident in a laboratory worker. The Lancet, 340(8814), 271-273. https://doi.org/10.1016/0140-6736(92)92358-M