Simian immunodeficiency virus needlestick accident in a laboratory worker

R. F. Khabbaz, T. Rowe, W. M. Heneine, J. E. Kaplan, T. M. Folks, C. A. Schable, J. R. George, C. Pau, B. S. Parekh, J. W. Curran, G. Schochetman, Michael Dale Lairmore, M. Murphey-Corb

Research output: Contribution to journalArticle

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Abstract

The macaque monkey infected with simian immunodeficiency virus (SIV) is an animal model of the acquired immunodeficiency syndrome. We investigated a laboratory worker who was exposed by needlestick accident to blood from an SIV-infected macaque. Seroreactivity to SIV developed within 3 months of exposure, with antibody titres peaking from the third to the fifth month and declining thereafter. Polymerase chain reaction for SIV sequences and cultures of peripheral-blood mononuclear cells failed to show infection. Inoculation of an SIV-negative monkey with blood from the worker did not cause infection. Animal-care and laboratory workers should adhere strictly to recommended procedures to avoid accidental exposures when working with SIV-infected animals or specimens.

Original languageEnglish (US)
Pages (from-to)271-273
Number of pages3
JournalThe Lancet
Volume340
Issue number8814
DOIs
StatePublished - Aug 1 1992
Externally publishedYes

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Needlestick Injuries
Simian Immunodeficiency Virus
Accidents
Macaca
Haplorhini
Laboratory Animals
Infection
Blood Cells
Acquired Immunodeficiency Syndrome
Animal Models
Polymerase Chain Reaction
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Khabbaz, R. F., Rowe, T., Heneine, W. M., Kaplan, J. E., Folks, T. M., Schable, C. A., ... Murphey-Corb, M. (1992). Simian immunodeficiency virus needlestick accident in a laboratory worker. The Lancet, 340(8814), 271-273. https://doi.org/10.1016/0140-6736(92)92358-M

Simian immunodeficiency virus needlestick accident in a laboratory worker. / Khabbaz, R. F.; Rowe, T.; Heneine, W. M.; Kaplan, J. E.; Folks, T. M.; Schable, C. A.; George, J. R.; Pau, C.; Parekh, B. S.; Curran, J. W.; Schochetman, G.; Lairmore, Michael Dale; Murphey-Corb, M.

In: The Lancet, Vol. 340, No. 8814, 01.08.1992, p. 271-273.

Research output: Contribution to journalArticle

Khabbaz, RF, Rowe, T, Heneine, WM, Kaplan, JE, Folks, TM, Schable, CA, George, JR, Pau, C, Parekh, BS, Curran, JW, Schochetman, G, Lairmore, MD & Murphey-Corb, M 1992, 'Simian immunodeficiency virus needlestick accident in a laboratory worker', The Lancet, vol. 340, no. 8814, pp. 271-273. https://doi.org/10.1016/0140-6736(92)92358-M
Khabbaz RF, Rowe T, Heneine WM, Kaplan JE, Folks TM, Schable CA et al. Simian immunodeficiency virus needlestick accident in a laboratory worker. The Lancet. 1992 Aug 1;340(8814):271-273. https://doi.org/10.1016/0140-6736(92)92358-M
Khabbaz, R. F. ; Rowe, T. ; Heneine, W. M. ; Kaplan, J. E. ; Folks, T. M. ; Schable, C. A. ; George, J. R. ; Pau, C. ; Parekh, B. S. ; Curran, J. W. ; Schochetman, G. ; Lairmore, Michael Dale ; Murphey-Corb, M. / Simian immunodeficiency virus needlestick accident in a laboratory worker. In: The Lancet. 1992 ; Vol. 340, No. 8814. pp. 271-273.
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