Abstract
Background: Simian immunodeficiency virus (SIV) infection leads to severe loss of intestinal CD4+ T cells and, as compared to peripheral blood, restoration of these cells is slow during antiretroviral therapy (ART). Mechanisms for this delay have not been examined in context of which specific CD4+ memory subsets or lost and fail to regenerate during ART. Methods: Fifteen rhesus macaques were infected with SIV, five of which received ART (FTC/PMPA) for 30 weeks. Viral loads were measured by real-time PCR. Flow cytometric analysis determined changes in T-cell subsets and their proliferative state. Results: Changes in proliferative CD4+ memory subsets during infection accelerated their depletion. This reduced the central memory CD4+ T-cell pool and contributed to slow CD4+ T-cell restoration during ART. Conclusion: There was a lack of restoration of the CD4+ central memory and effector memory T-cell subsets in gut-associated lymphoid tissue during ART, which may contribute to the altered intestinal T-cell homeostasis in SIV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 219-227 |
| Number of pages | 9 |
| Journal | Journal of Medical Primatology |
| Volume | 36 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Aug 2007 |
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Keywords
- Antiretroviral therapy
- Central memory
- Gut-associated lymphoid tissue
- Memory homeostasis
- Simian immunodiciency virus
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy. / Verhoeven, D.; Sankaran-Walters, Sumathi; Dandekar, Satya.
In: Journal of Medical Primatology, Vol. 36, No. 4-5, 08.2007, p. 219-227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy
AU - Verhoeven, D.
AU - Sankaran-Walters, Sumathi
AU - Dandekar, Satya
PY - 2007/8
Y1 - 2007/8
N2 - Background: Simian immunodeficiency virus (SIV) infection leads to severe loss of intestinal CD4+ T cells and, as compared to peripheral blood, restoration of these cells is slow during antiretroviral therapy (ART). Mechanisms for this delay have not been examined in context of which specific CD4+ memory subsets or lost and fail to regenerate during ART. Methods: Fifteen rhesus macaques were infected with SIV, five of which received ART (FTC/PMPA) for 30 weeks. Viral loads were measured by real-time PCR. Flow cytometric analysis determined changes in T-cell subsets and their proliferative state. Results: Changes in proliferative CD4+ memory subsets during infection accelerated their depletion. This reduced the central memory CD4+ T-cell pool and contributed to slow CD4+ T-cell restoration during ART. Conclusion: There was a lack of restoration of the CD4+ central memory and effector memory T-cell subsets in gut-associated lymphoid tissue during ART, which may contribute to the altered intestinal T-cell homeostasis in SIV infection.
AB - Background: Simian immunodeficiency virus (SIV) infection leads to severe loss of intestinal CD4+ T cells and, as compared to peripheral blood, restoration of these cells is slow during antiretroviral therapy (ART). Mechanisms for this delay have not been examined in context of which specific CD4+ memory subsets or lost and fail to regenerate during ART. Methods: Fifteen rhesus macaques were infected with SIV, five of which received ART (FTC/PMPA) for 30 weeks. Viral loads were measured by real-time PCR. Flow cytometric analysis determined changes in T-cell subsets and their proliferative state. Results: Changes in proliferative CD4+ memory subsets during infection accelerated their depletion. This reduced the central memory CD4+ T-cell pool and contributed to slow CD4+ T-cell restoration during ART. Conclusion: There was a lack of restoration of the CD4+ central memory and effector memory T-cell subsets in gut-associated lymphoid tissue during ART, which may contribute to the altered intestinal T-cell homeostasis in SIV infection.
KW - Antiretroviral therapy
KW - Central memory
KW - Gut-associated lymphoid tissue
KW - Memory homeostasis
KW - Simian immunodiciency virus
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UR - http://www.scopus.com/inward/citedby.url?scp=34547100323&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0684.2007.00239.x
DO - 10.1111/j.1600-0684.2007.00239.x
M3 - Article
C2 - 17669210
AN - SCOPUS:34547100323
VL - 36
SP - 219
EP - 227
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 4-5
ER -