Simian immunodeficiency virus in kidney cell cultures from highly infected rhesus macaques (Macaca mulatta)

P. Lena, Paul A Luciw

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Trace amounts of simian immunodeficiency virus (SIV) proviral DNA were detected in monolayers of primary kidney cells from two rhesus macaques (Macaca mulatta) heavily infected with the highly pathogenic strain SIV mac251. There was no detectable infectious SIV in the supernatant from the kidney cell cultures obtained from either monkey. However, infectious SIV was rescued by co-culture of kidney cells with a permissive lymphoid cell line. Macrophages, present in these cultures, may be the reservoir for the proviral genomes.

Original languageEnglish (US)
Pages (from-to)845-847
Number of pages3
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume356
Issue number1410
DOIs
StatePublished - Jun 29 2001
Externally publishedYes

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Keywords

  • Kidney
  • Macaque
  • Macrophage
  • Primary cells
  • Simian immunodeficiency virus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

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