Abstract
Trace amounts of simian immunodeficiency virus (SIV) proviral DNA were detected in monolayers of primary kidney cells from two rhesus macaques (Macaca mulatta) heavily infected with the highly pathogenic strain SIV mac251. There was no detectable infectious SIV in the supernatant from the kidney cell cultures obtained from either monkey. However, infectious SIV was rescued by co-culture of kidney cells with a permissive lymphoid cell line. Macrophages, present in these cultures, may be the reservoir for the proviral genomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 845-847 |
| Number of pages | 3 |
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Volume | 356 |
| Issue number | 1410 |
| DOIs | |
| State | Published - Jun 29 2001 |
| Externally published | Yes |
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Keywords
- Kidney
- Macaque
- Macrophage
- Primary cells
- Simian immunodeficiency virus
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Agricultural and Biological Sciences (miscellaneous)