Simian immunodeficiency virus in kidney cell cultures from highly infected rhesus macaques (Macaca mulatta)

P. Lena; Paul A Luciw

doi:10.1098/rstb.2001.0871

Simian immunodeficiency virus in kidney cell cultures from highly infected rhesus macaques (Macaca mulatta)

P. Lena, Paul A Luciw

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Trace amounts of simian immunodeficiency virus (SIV) proviral DNA were detected in monolayers of primary kidney cells from two rhesus macaques (Macaca mulatta) heavily infected with the highly pathogenic strain SIV mac251. There was no detectable infectious SIV in the supernatant from the kidney cell cultures obtained from either monkey. However, infectious SIV was rescued by co-culture of kidney cells with a permissive lymphoid cell line. Macrophages, present in these cultures, may be the reservoir for the proviral genomes.

Original language	English (US)
Pages (from-to)	845-847
Number of pages	3
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	356
Issue number	1410
DOIs	https://doi.org/10.1098/rstb.2001.0871
State	Published - Jun 29 2001
Externally published	Yes

Keywords

Kidney
Macaque
Macrophage
Primary cells
Simian immunodeficiency virus

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Agricultural and Biological Sciences (miscellaneous)

Access to Document

10.1098/rstb.2001.0871

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Cite this

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AU - Luciw, Paul A

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AB - Trace amounts of simian immunodeficiency virus (SIV) proviral DNA were detected in monolayers of primary kidney cells from two rhesus macaques (Macaca mulatta) heavily infected with the highly pathogenic strain SIV mac251. There was no detectable infectious SIV in the supernatant from the kidney cell cultures obtained from either monkey. However, infectious SIV was rescued by co-culture of kidney cells with a permissive lymphoid cell line. Macrophages, present in these cultures, may be the reservoir for the proviral genomes.

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KW - Macrophage

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KW - Simian immunodeficiency virus

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