Silicone implants and lymphoma

The role of inflammation

Mojca Bizjak, Carlo Selmi, Sonja Praprotnik, Or Bruck, Carlo Perricone, Michael Ehrenfeld, Yehuda Shoenfeld

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The risk of hematological malignancies is mainly determined by genetic background, age, sex, race and ethnicity, geographic location, exposure to certain chemicals and radiation; along with the more recently proposed immune factors such as chronic inflammation, immunodeficiencies, autoimmunity, and infections. Paradigmatic examples include the development of lymphoma in Sjögren's syndrome and Hashimoto thyroiditis, gastric MALT lymphoma in Helicobacter pylori infection, or lymphomas associated with infections by Epstein-Barr virus, human herpes virus 8 (HHV 8) and leukemia/lymphoma virus 1 (HTLV-1). A growing number of reports indicates an increased risk of lymphoma, particularly of the anaplastic large cell (ALCL) type. The implants, specifically those used in the past, elicit chronic stimulation of the immune system against the prosthetic material. This is particularly the case in genetically susceptible hosts. We suggest that polyclonal activation may result in monoclonality in those at risk hosts, ultimately leading to lymphoma. We suggest that patients with an inflammatory response against silicone implants be monitored carefully.

Original languageEnglish (US)
JournalJournal of Autoimmunity
DOIs
StateAccepted/In press - Jul 14 2015
Externally publishedYes

Fingerprint

Silicones
Lymphoma
Inflammation
Viruses
Anaplastic Large-Cell Lymphoma
Geographic Locations
Marginal Zone B-Cell Lymphoma
Hashimoto Disease
Human T-lymphotropic virus 1
Epstein-Barr Virus Infections
Immunologic Factors
Helicobacter Infections
Hematologic Neoplasms
Autoimmunity
Helicobacter pylori
Immune System
Leukemia
Radiation
Infection

Keywords

  • Adjuvant
  • Breast implant
  • Chronic immune system stimulation
  • Lymphoma
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Bizjak, M., Selmi, C., Praprotnik, S., Bruck, O., Perricone, C., Ehrenfeld, M., & Shoenfeld, Y. (Accepted/In press). Silicone implants and lymphoma: The role of inflammation. Journal of Autoimmunity. https://doi.org/10.1016/j.jaut.2015.08.009

Silicone implants and lymphoma : The role of inflammation. / Bizjak, Mojca; Selmi, Carlo; Praprotnik, Sonja; Bruck, Or; Perricone, Carlo; Ehrenfeld, Michael; Shoenfeld, Yehuda.

In: Journal of Autoimmunity, 14.07.2015.

Research output: Contribution to journalArticle

Bizjak, M, Selmi, C, Praprotnik, S, Bruck, O, Perricone, C, Ehrenfeld, M & Shoenfeld, Y 2015, 'Silicone implants and lymphoma: The role of inflammation', Journal of Autoimmunity. https://doi.org/10.1016/j.jaut.2015.08.009
Bizjak M, Selmi C, Praprotnik S, Bruck O, Perricone C, Ehrenfeld M et al. Silicone implants and lymphoma: The role of inflammation. Journal of Autoimmunity. 2015 Jul 14. https://doi.org/10.1016/j.jaut.2015.08.009
Bizjak, Mojca ; Selmi, Carlo ; Praprotnik, Sonja ; Bruck, Or ; Perricone, Carlo ; Ehrenfeld, Michael ; Shoenfeld, Yehuda. / Silicone implants and lymphoma : The role of inflammation. In: Journal of Autoimmunity. 2015.
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