Silicone implants and lymphoma: The role of inflammation

Mojca Bizjak, Carlo Selmi, Sonja Praprotnik, Or Bruck, Carlo Perricone, Michael Ehrenfeld, Yehuda Shoenfeld

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The risk of hematological malignancies is mainly determined by genetic background, age, sex, race and ethnicity, geographic location, exposure to certain chemicals and radiation; along with the more recently proposed immune factors such as chronic inflammation, immunodeficiencies, autoimmunity, and infections. Paradigmatic examples include the development of lymphoma in Sjögren's syndrome and Hashimoto thyroiditis, gastric MALT lymphoma in Helicobacter pylori infection, or lymphomas associated with infections by Epstein-Barr virus, human herpes virus 8 (HHV 8) and leukemia/lymphoma virus 1 (HTLV-1). A growing number of reports indicates an increased risk of lymphoma, particularly of the anaplastic large cell (ALCL) type. The implants, specifically those used in the past, elicit chronic stimulation of the immune system against the prosthetic material. This is particularly the case in genetically susceptible hosts. We suggest that polyclonal activation may result in monoclonality in those at risk hosts, ultimately leading to lymphoma. We suggest that patients with an inflammatory response against silicone implants be monitored carefully.

Original languageEnglish (US)
JournalJournal of Autoimmunity
DOIs
StateAccepted/In press - Jul 14 2015
Externally publishedYes

Keywords

  • Adjuvant
  • Breast implant
  • Chronic immune system stimulation
  • Lymphoma
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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  • Cite this

    Bizjak, M., Selmi, C., Praprotnik, S., Bruck, O., Perricone, C., Ehrenfeld, M., & Shoenfeld, Y. (Accepted/In press). Silicone implants and lymphoma: The role of inflammation. Journal of Autoimmunity. https://doi.org/10.1016/j.jaut.2015.08.009