Signaling network of the Btk family kinases

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Abstract

The Btk family kinases represent new members of non-receptor tyrosine kinases, which include Btk/Atk, Itk/Emt/Tsk, Bmx/Etk, and Tec. They are characterized by having four structural modules: PH (pleckstrin homology) domain, SH3 (Src homology 3) domain, SH2 (Src homology 2) domain and kinase (Src homology 1) domain. Increasing evidence suggests that, like Src-family kinases, Btk family kinases play central but diverse modulatory roles in various cellular processes. They participate in signal transduction in response to virtually all types of extracellular stimuli which are transmitted by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen-receptors and integrins. They are regulated by many non-receptor tyrosine kinases such as Src, Jak, Syk and FAK family kinases. In turn, they regulate many of major signaling pathways including those of PI3K, PLCγ and PKC. Both genetic and biochemical approaches have been used to dissect the signaling pathways and elucidate their roles in growth, differentiation and apoptosis. An emerging new role of this family of kinases is cytoskeletal reorganization and cell motility. The physiological importance of these kinases was amply demonstrated by their link to the development of immunodeficiency diseases, due to germ-line mutations. The present article attempts to review the structure and functions of Btk family kinases by summarizing our current knowledge on the interacting partners associated with the different modules of the kinases and the diverse signaling pathways in which they are involved.

Original languageEnglish (US)
Pages (from-to)5651-5661
Number of pages11
JournalOncogene
Volume19
Issue number49
StatePublished - Nov 20 2000

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Phosphotransferases
src Homology Domains
Protein-Tyrosine Kinases
Antigen Receptors
Cytokine Receptors
Growth Factor Receptors
src-Family Kinases
Germ-Line Mutation
G-Protein-Coupled Receptors
Phosphatidylinositol 3-Kinases
Integrins
Cell Movement
Molecular Biology
Signal Transduction
Apoptosis
Growth

Keywords

  • Apoptosis
  • Btk
  • Motility
  • PH domain
  • Tyrosine kinase

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Signaling network of the Btk family kinases. / Qiu, Yun; Kung, Hsing-Jien.

In: Oncogene, Vol. 19, No. 49, 20.11.2000, p. 5651-5661.

Research output: Contribution to journalArticle

Qiu, Y & Kung, H-J 2000, 'Signaling network of the Btk family kinases', Oncogene, vol. 19, no. 49, pp. 5651-5661.
Qiu, Yun ; Kung, Hsing-Jien. / Signaling network of the Btk family kinases. In: Oncogene. 2000 ; Vol. 19, No. 49. pp. 5651-5661.
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