Signaling mechanisms controlling cranial placode neurogenesis and delamination

Rhonda N T Lassiter, Michael R. Stark, Tianyu Zhao, Chengji Zhou

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The neurogenic cranial placodes are a unique transient epithelial niche of neural progenitor cells that give rise to multiple derivatives of the peripheral nervous system, particularly, the sensory neurons. Placode neurogenesis occurs throughout an extended period of time with epithelial cells continually recruited as neural progenitor cells. Sensory neuron development in the trigeminal, epibranchial, otic, and olfactory placodes coincides with detachment of these neuroblasts from the encompassing epithelial sheet, leading to delamination and ingression into the mesenchyme where they continue to differentiate as neurons. Multiple signaling pathways are known to direct placodal development. This review defines the signaling pathways working at the finite spatiotemporal period when neuronal selection within the placodes occurs, and neuroblasts concomitantly delaminate from the epithelium. Examining neurogenesis and delamination after initial placodal patterning and specification has revealed a common trend throughout the neurogenic placodes, which suggests that both activated FGF and attenuated Notch signaling activities are required for neurogenesis and changes in epithelial cell adhesion leading to delamination. We also address the varying roles of other pathways such as the Wnt and BMP signaling families during sensory neurogenesis and neuroblast delamination in the differing placodes.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalDevelopmental Biology
Volume389
Issue number1
DOIs
StatePublished - May 1 2014

Fingerprint

Neurogenesis
Sensory Receptor Cells
Stem Cells
Epithelial Cells
Peripheral Nervous System
Mesoderm
Cell Adhesion
Ear
Epithelium
Neurons

Keywords

  • BMP
  • Cranial placodes
  • Delamination
  • FGF
  • Neurogenesis
  • Notch
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Molecular Biology

Cite this

Signaling mechanisms controlling cranial placode neurogenesis and delamination. / Lassiter, Rhonda N T; Stark, Michael R.; Zhao, Tianyu; Zhou, Chengji.

In: Developmental Biology, Vol. 389, No. 1, 01.05.2014, p. 39-49.

Research output: Contribution to journalArticle

Lassiter, Rhonda N T ; Stark, Michael R. ; Zhao, Tianyu ; Zhou, Chengji. / Signaling mechanisms controlling cranial placode neurogenesis and delamination. In: Developmental Biology. 2014 ; Vol. 389, No. 1. pp. 39-49.
@article{f478f899b62f44be8e01ddd1b6f50acd,
title = "Signaling mechanisms controlling cranial placode neurogenesis and delamination",
abstract = "The neurogenic cranial placodes are a unique transient epithelial niche of neural progenitor cells that give rise to multiple derivatives of the peripheral nervous system, particularly, the sensory neurons. Placode neurogenesis occurs throughout an extended period of time with epithelial cells continually recruited as neural progenitor cells. Sensory neuron development in the trigeminal, epibranchial, otic, and olfactory placodes coincides with detachment of these neuroblasts from the encompassing epithelial sheet, leading to delamination and ingression into the mesenchyme where they continue to differentiate as neurons. Multiple signaling pathways are known to direct placodal development. This review defines the signaling pathways working at the finite spatiotemporal period when neuronal selection within the placodes occurs, and neuroblasts concomitantly delaminate from the epithelium. Examining neurogenesis and delamination after initial placodal patterning and specification has revealed a common trend throughout the neurogenic placodes, which suggests that both activated FGF and attenuated Notch signaling activities are required for neurogenesis and changes in epithelial cell adhesion leading to delamination. We also address the varying roles of other pathways such as the Wnt and BMP signaling families during sensory neurogenesis and neuroblast delamination in the differing placodes.",
keywords = "BMP, Cranial placodes, Delamination, FGF, Neurogenesis, Notch, Wnt",
author = "Lassiter, {Rhonda N T} and Stark, {Michael R.} and Tianyu Zhao and Chengji Zhou",
year = "2014",
month = "5",
day = "1",
doi = "10.1016/j.ydbio.2013.11.025",
language = "English (US)",
volume = "389",
pages = "39--49",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Signaling mechanisms controlling cranial placode neurogenesis and delamination

AU - Lassiter, Rhonda N T

AU - Stark, Michael R.

AU - Zhao, Tianyu

AU - Zhou, Chengji

PY - 2014/5/1

Y1 - 2014/5/1

N2 - The neurogenic cranial placodes are a unique transient epithelial niche of neural progenitor cells that give rise to multiple derivatives of the peripheral nervous system, particularly, the sensory neurons. Placode neurogenesis occurs throughout an extended period of time with epithelial cells continually recruited as neural progenitor cells. Sensory neuron development in the trigeminal, epibranchial, otic, and olfactory placodes coincides with detachment of these neuroblasts from the encompassing epithelial sheet, leading to delamination and ingression into the mesenchyme where they continue to differentiate as neurons. Multiple signaling pathways are known to direct placodal development. This review defines the signaling pathways working at the finite spatiotemporal period when neuronal selection within the placodes occurs, and neuroblasts concomitantly delaminate from the epithelium. Examining neurogenesis and delamination after initial placodal patterning and specification has revealed a common trend throughout the neurogenic placodes, which suggests that both activated FGF and attenuated Notch signaling activities are required for neurogenesis and changes in epithelial cell adhesion leading to delamination. We also address the varying roles of other pathways such as the Wnt and BMP signaling families during sensory neurogenesis and neuroblast delamination in the differing placodes.

AB - The neurogenic cranial placodes are a unique transient epithelial niche of neural progenitor cells that give rise to multiple derivatives of the peripheral nervous system, particularly, the sensory neurons. Placode neurogenesis occurs throughout an extended period of time with epithelial cells continually recruited as neural progenitor cells. Sensory neuron development in the trigeminal, epibranchial, otic, and olfactory placodes coincides with detachment of these neuroblasts from the encompassing epithelial sheet, leading to delamination and ingression into the mesenchyme where they continue to differentiate as neurons. Multiple signaling pathways are known to direct placodal development. This review defines the signaling pathways working at the finite spatiotemporal period when neuronal selection within the placodes occurs, and neuroblasts concomitantly delaminate from the epithelium. Examining neurogenesis and delamination after initial placodal patterning and specification has revealed a common trend throughout the neurogenic placodes, which suggests that both activated FGF and attenuated Notch signaling activities are required for neurogenesis and changes in epithelial cell adhesion leading to delamination. We also address the varying roles of other pathways such as the Wnt and BMP signaling families during sensory neurogenesis and neuroblast delamination in the differing placodes.

KW - BMP

KW - Cranial placodes

KW - Delamination

KW - FGF

KW - Neurogenesis

KW - Notch

KW - Wnt

UR - http://www.scopus.com/inward/record.url?scp=84897428996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897428996&partnerID=8YFLogxK

U2 - 10.1016/j.ydbio.2013.11.025

DO - 10.1016/j.ydbio.2013.11.025

M3 - Article

C2 - 24315854

AN - SCOPUS:84897428996

VL - 389

SP - 39

EP - 49

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 1

ER -