Signaling and transcription in T helper development

Kenneth M. Murphy, Wenjun Ouyang, J. David Farrar, Jianfei Yang, Sheila Ranganath, Helene Asnagli, Maryam Afkarian, Theresa L. Murphy

Research output: Contribution to journalReview article

507 Citations (Scopus)

Abstract

The recognition of polarized T cell subsets defined by cytokine production was followed by a search to define the factors controlling this phenomenon. Suitable in vitro systems allowed the development of cytokine 'recipes' that induced rapid polarization of naive T cells into Th1 or Th2 populations. The next phase of work over the past several years has begun to define the intracellular processes set into motion during Th1/Th2 development, particularly by the strongly polarizing cytokines IL-12 and IL- 4. Although somewhat incomplete, what has emerged is a richly detailed tapestry of signaling and transcription, controlling an important T cell developmental switch. In addition several new mediators of control have emerged, including IL-18, the intriguing Th2-selective T1/ST2 product, and heterogeneity in dendritic cells capable of directing cytokine-independent Th development.

Original languageEnglish (US)
Pages (from-to)451-494
Number of pages44
JournalAnnual Review of Immunology
Volume18
DOIs
StatePublished - Jun 27 2000
Externally publishedYes

Fingerprint

Cytokines
T-Lymphocytes
Interleukin-18
T-Lymphocyte Subsets
Interleukin-12
Interleukin-4
Dendritic Cells
Population
In Vitro Techniques

Keywords

  • Cytokines
  • Gene expression
  • Signaling
  • Th subsets
  • Transcription

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Murphy, K. M., Ouyang, W., Farrar, J. D., Yang, J., Ranganath, S., Asnagli, H., ... Murphy, T. L. (2000). Signaling and transcription in T helper development. Annual Review of Immunology, 18, 451-494. https://doi.org/10.1146/annurev.immunol.18.1.451

Signaling and transcription in T helper development. / Murphy, Kenneth M.; Ouyang, Wenjun; Farrar, J. David; Yang, Jianfei; Ranganath, Sheila; Asnagli, Helene; Afkarian, Maryam; Murphy, Theresa L.

In: Annual Review of Immunology, Vol. 18, 27.06.2000, p. 451-494.

Research output: Contribution to journalReview article

Murphy, KM, Ouyang, W, Farrar, JD, Yang, J, Ranganath, S, Asnagli, H, Afkarian, M & Murphy, TL 2000, 'Signaling and transcription in T helper development', Annual Review of Immunology, vol. 18, pp. 451-494. https://doi.org/10.1146/annurev.immunol.18.1.451
Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H et al. Signaling and transcription in T helper development. Annual Review of Immunology. 2000 Jun 27;18:451-494. https://doi.org/10.1146/annurev.immunol.18.1.451
Murphy, Kenneth M. ; Ouyang, Wenjun ; Farrar, J. David ; Yang, Jianfei ; Ranganath, Sheila ; Asnagli, Helene ; Afkarian, Maryam ; Murphy, Theresa L. / Signaling and transcription in T helper development. In: Annual Review of Immunology. 2000 ; Vol. 18. pp. 451-494.
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