Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures

Agustini Utari, Weerasak Chonchaiya, Susan M. Rivera, Andrea Schneider, Randi J Hagerman, Sultana M H Faradz, Iryna M. Ethell, Danh V. Nguyen

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed 50 patients with fragile X syndrome who received minocycline for at least 2 weeks and found that the most common reported side effect is gastrointestinal difficulty, including loss of appetite. The families reported an improvement in language and behavioral areas. Outcome measures in the design of future randomized clinical trials should include both behavioral and language measures. As with any other treatments, we emphasize that randomized clinical trials are needed to determine the efficacy of minocycline in fragile X syndrome.

Original languageEnglish (US)
Pages (from-to)433-443
Number of pages11
JournalAmerican Journal on Intellectual and Developmental Disabilities
Volume115
Issue number5
DOIs
StatePublished - Sep 2010

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ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Developmental and Educational Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Medicine(all)

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