Abstract
Summary Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 859-871 |
| Number of pages | 13 |
| Journal | Cell |
| Volume | 164 |
| Issue number | 5 |
| DOIs | |
| State | Published - Feb 25 2016 |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. / Charbonneau, Mark R.; O'Donnell, David; Blanton, Laura V.; Totten, Sarah M.; Davis, Jasmine C C; Barratt, Michael J.; Cheng, Jiye; Guruge, Janaki; Talcott, Michael; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; Wu, Chao; Struckmeyer, Tedd; Barile, Daniela; Mangani, Charles; Jorgensen, Josh; Fan, Yue Mei; Maleta, Kenneth; Dewey, Kathryn G.; Ashorn, Per; Newgard, Christopher B.; Lebrilla, Carlito B; Mills, David A.; Gordon, Jeffrey I.
In: Cell, Vol. 164, No. 5, 25.02.2016, p. 859-871.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition
AU - Charbonneau, Mark R.
AU - O'Donnell, David
AU - Blanton, Laura V.
AU - Totten, Sarah M.
AU - Davis, Jasmine C C
AU - Barratt, Michael J.
AU - Cheng, Jiye
AU - Guruge, Janaki
AU - Talcott, Michael
AU - Bain, James R.
AU - Muehlbauer, Michael J.
AU - Ilkayeva, Olga
AU - Wu, Chao
AU - Struckmeyer, Tedd
AU - Barile, Daniela
AU - Mangani, Charles
AU - Jorgensen, Josh
AU - Fan, Yue Mei
AU - Maleta, Kenneth
AU - Dewey, Kathryn G.
AU - Ashorn, Per
AU - Newgard, Christopher B.
AU - Lebrilla, Carlito B
AU - Mills, David A.
AU - Gordon, Jeffrey I.
PY - 2016/2/25
Y1 - 2016/2/25
N2 - Summary Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.
AB - Summary Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.
UR - http://www.scopus.com/inward/record.url?scp=84959476433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959476433&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2016.01.024
DO - 10.1016/j.cell.2016.01.024
M3 - Article
VL - 164
SP - 859
EP - 871
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -