Abstract
para-Nitrophenol-tagged sialyl galactosides containing sialic acid derivatives in which the C5 hydroxyl group of sialic acids was systematically substituted with a hydrogen, a fluorine, a methoxyl or an azido group were successfully synthesized using an efficient chemoenzymatic approach. These compounds were used as valuable probes in high-throughput screening assays to study the importance of the C5 hydroxyl group of sialic acid in the recognition and the cleavage of sialoside substrates by bacterial sialidases.
Original language | English (US) |
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Pages (from-to) | 5137-5145 |
Number of pages | 9 |
Journal | Organic and Biomolecular Chemistry |
Volume | 7 |
Issue number | 24 |
DOIs | |
State | Published - 2009 |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Biochemistry