Abstract
para-Nitrophenol-tagged sialyl galactosides containing sialic acid derivatives in which the C5 hydroxyl group of sialic acids was systematically substituted with a hydrogen, a fluorine, a methoxyl or an azido group were successfully synthesized using an efficient chemoenzymatic approach. These compounds were used as valuable probes in high-throughput screening assays to study the importance of the C5 hydroxyl group of sialic acid in the recognition and the cleavage of sialoside substrates by bacterial sialidases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5137-5145 |
| Number of pages | 9 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 7 |
| Issue number | 24 |
| DOIs | |
| State | Published - 2009 |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Biochemistry
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Cite this
Cao, H., Li, Y., Lau, K., Muthana, S., Yu, H., Cheng, J., Chokhawala, H. A., Sugiarto, G., Zhang, L., & Chen, X. (2009). Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. Organic and Biomolecular Chemistry, 7(24), 5137-5145. https://doi.org/10.1039/b916305k