Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

Aaron Chen, Deborah Lieu, Lauren Freschauf, Valerie Lew, Himanshu Sharma, Jiaxian Wang, Diep Nguyen, Ioannis Karakikes, Roger J. Hajjar, Ajay Gopinathan, Elliot Botvinick, Charless C. Fowlkes, Ronald A. Li, Michelle Khine

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

Original languageEnglish (US)
Pages (from-to)5785-5791
Number of pages7
JournalAdvanced Materials
Volume23
Issue number48
DOIs
StatePublished - Dec 22 2011

Keywords

  • action potential propagation
  • biomimetics
  • contact guidance
  • human embryonic stem cell derived cardiomyocytes

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Chen, A., Lieu, D., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R. J., Gopinathan, A., Botvinick, E., Fowlkes, C. C., Li, R. A., & Khine, M. (2011). Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Advanced Materials, 23(48), 5785-5791. https://doi.org/10.1002/adma.201103463