Experiments were conducted to determine whether interactions in disposition between two insecticides might occur within the first few hours of exposure. Levels of both [14C]endrin and [3H]DDT were monitored in serum, gall bladders, and whole bodies during pre- and post-exposures to each compound or analogs, as well as during concurrent exposures in mosquitofish (Gambusia affinis). Prior exposure to DDT for four hr generally reduced endrin accumulation in serum, gall bladders and whole bodies, whereas prior exposure to endrin exerted little effect on DDT accumulation. Simultaneous exposure to DDT and endrin reduced DDT accumulation in the gall bladder at all times and in the whole body during the first two hr; endrin accumulation was generally reduced in the gall bladder and whole body. Endrin levels in fish exposed subsequently to only DDT or DDE were significantly higher in the gall bladder at all times after 0.5 hr and were reduced in the whole body at all times tested, compared to fish exposed subsequently only to uncontaminated water. While endrin post-treatment had no effect on DDT levels in the gall bladder, aldrin and dieldrin exposure resulted in significantly higher gall bladder levels of DDT compared to fish exposed subsequently only to uncontaminated water. The insecticide interactions observed may be the result of competition for and/or displacement of insecticides from mutual binding sites.
|Original language||English (US)|
|Number of pages||6|
|Journal||Archives of Environmental Contamination and Toxicology|
|State||Published - May 1985|
ASJC Scopus subject areas
- Environmental Chemistry
- Environmental Science(all)