Short-Term Experience with Off-Pump vs On-Pump Implantation of the HeartWare Left Ventricular Assist Device

Igor D. Gregoric, Rajko Radovancevic, Mehmet H. Akay, Mateja K. Jezovnik, Sriram Nathan, Manish Patel, Jayeshkumar A. Patel, Elena Nedelcu, Nghia D. Nguyen, Pranav Loyalka, Biswajit Kar

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Implantation of left ventricular assist devices (LVAD) while avoiding cardiopulmonary bypass (CPB) may decrease bleeding and improve postoperative recovery. To understand the effectiveness of this approach, we reviewed the charts of 26 patients who underwent HeartWare left ventricular assist device (HVAD) implantation without use of CPB (off-CPB group) and 22 patients who had HVAD implanted with CPB (CPB group) with an emphasis on the 30-day postoperative period. Preoperatively, both groups had similar demographic, functional, and hemodynamic characteristics. Off-CPB patients had significantly shorter surgery times compared to CPB patients 188.5 (161.5-213.3) min vs 265.0 (247.5-299.5) min, respectively; p<0.001. Blood transfusion requirements during surgery and within the postoperative 48-hour period were significantly lower in the off-CPB group compared to the CPB group (OR 5.9 95% CI (1.1-31.1, p=0.042). Compared to the CPB group, the off-CPB group patients had a shorter intubation time, 21 (17.4-48.5) hours vs 41 (20.6-258.4) hours; p=0.042. Intensive care unit stay was 7.0 (4.75-13.5) days for off-CPB vs. 10.0 (6.0-19.0) days for CPB (P=0.256). The off-CPB approach allows HVAD to be implanted quickly with significantly less perioperative bleeding and transfusion requirements and facilitates postoperative rehabilitation.

Original languageEnglish (US)
JournalASAIO Journal
StateAccepted/In press - Sep 22 2016
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biophysics
  • Medicine(all)
  • Biomaterials
  • Biomedical Engineering


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