Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California

Jennifer K. Mann, John R. Balmes, Tim A. Bruckner, Kathleen M. Mortimer, Helene G Margolis, Boriana Pratt, S. Katharine Hammond, Frederick W. Lurmann, Ira B. Tager

Research output: Contribution to journalArticle

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Abstract

Background: Although studies have demonstrated that air pollution is associated with exacerbation of asthma symptoms in children with asthma, little is known about the susceptibility of subgroups, particularly those with atopy. Objective: This study was designed to evaluate our a priori hypothesis that identifiable subgroups of asthmatic children are more likely to wheeze with exposure to ambient air pollution. Methods: A cohort of 315 children with asthma, 6-11 years of age, was recruited for longitudinal follow-up in Fresno, California (USA). During the baseline visit, children were administered a respiratory symptom questionnaire and allergen skin-prick test. Three times a year, participants completed 14-day panels during which they answered symptom questions twice daily. Ambient air quality data from a central monitoring station were used to assign exposures to the following pollutants: particulate matter ≤ 2.5 μm in aerodynamic diameter, particulate matter between 2.5 and 10 μm in aerodynamic diameter (PM 10-2.5), elemental carbon, nitrogen dioxide (NO 2), nitrate, and O 3. Results: For the group as a whole, wheeze was significantly associated with short-term exposures to NO 2 [odds ratio (OR) = 1.10 for 8.7-ppb increase; 95% confidence interval (CI), 1.02-1.20] and PM 10-2.5 (OR = 1.11 for 14.7-μg/m 3 increase; 95% CI, 1.01-1.22). The association with wheeze was stronger for these two pollutants in children who were skin-test positive to cat or common fungi and in boys with mild intermittent asthma. Conclusion: A pollutant associated with traffic emissions, NO2, and a pollutant with bioactive constituents, PM 10-2.5, were associated with increased risk of wheeze in asthmatic children living in Fresno, California. Children with atopy to cat or common fungi and boys with mild intermittent asthma were the subgroups for which we observed the largest associations.

Original languageEnglish (US)
Pages (from-to)1497-1502
Number of pages6
JournalEnvironmental Health Perspectives
Volume118
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Air Pollution
Asthma
Particulate Matter
Skin Tests
Cats
Fungi
Odds Ratio
Confidence Intervals
Nitrogen Dioxide
Carbon Dioxide
Nitrates
Allergens
Air

Keywords

  • Air pollution
  • Asthma
  • Atopy
  • Coarse particulate matter
  • Nitrogen dioxide
  • Wheeze

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Mann, J. K., Balmes, J. R., Bruckner, T. A., Mortimer, K. M., Margolis, H. G., Pratt, B., ... Tager, I. B. (2010). Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environmental Health Perspectives, 118(10), 1497-1502. https://doi.org/10.1289/ehp.0901292

Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. / Mann, Jennifer K.; Balmes, John R.; Bruckner, Tim A.; Mortimer, Kathleen M.; Margolis, Helene G; Pratt, Boriana; Katharine Hammond, S.; Lurmann, Frederick W.; Tager, Ira B.

In: Environmental Health Perspectives, Vol. 118, No. 10, 10.2010, p. 1497-1502.

Research output: Contribution to journalArticle

Mann, JK, Balmes, JR, Bruckner, TA, Mortimer, KM, Margolis, HG, Pratt, B, Katharine Hammond, S, Lurmann, FW & Tager, IB 2010, 'Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California', Environmental Health Perspectives, vol. 118, no. 10, pp. 1497-1502. https://doi.org/10.1289/ehp.0901292
Mann, Jennifer K. ; Balmes, John R. ; Bruckner, Tim A. ; Mortimer, Kathleen M. ; Margolis, Helene G ; Pratt, Boriana ; Katharine Hammond, S. ; Lurmann, Frederick W. ; Tager, Ira B. / Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. In: Environmental Health Perspectives. 2010 ; Vol. 118, No. 10. pp. 1497-1502.
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abstract = "Background: Although studies have demonstrated that air pollution is associated with exacerbation of asthma symptoms in children with asthma, little is known about the susceptibility of subgroups, particularly those with atopy. Objective: This study was designed to evaluate our a priori hypothesis that identifiable subgroups of asthmatic children are more likely to wheeze with exposure to ambient air pollution. Methods: A cohort of 315 children with asthma, 6-11 years of age, was recruited for longitudinal follow-up in Fresno, California (USA). During the baseline visit, children were administered a respiratory symptom questionnaire and allergen skin-prick test. Three times a year, participants completed 14-day panels during which they answered symptom questions twice daily. Ambient air quality data from a central monitoring station were used to assign exposures to the following pollutants: particulate matter ≤ 2.5 μm in aerodynamic diameter, particulate matter between 2.5 and 10 μm in aerodynamic diameter (PM 10-2.5), elemental carbon, nitrogen dioxide (NO 2), nitrate, and O 3. Results: For the group as a whole, wheeze was significantly associated with short-term exposures to NO 2 [odds ratio (OR) = 1.10 for 8.7-ppb increase; 95{\%} confidence interval (CI), 1.02-1.20] and PM 10-2.5 (OR = 1.11 for 14.7-μg/m 3 increase; 95{\%} CI, 1.01-1.22). The association with wheeze was stronger for these two pollutants in children who were skin-test positive to cat or common fungi and in boys with mild intermittent asthma. Conclusion: A pollutant associated with traffic emissions, NO2, and a pollutant with bioactive constituents, PM 10-2.5, were associated with increased risk of wheeze in asthmatic children living in Fresno, California. Children with atopy to cat or common fungi and boys with mild intermittent asthma were the subgroups for which we observed the largest associations.",
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