Short- and long-term therapy of mild essential hypertension with timolol

Fred J. Harris, Melvin Tonkin, Craig Pratt, Anthony N. DeMaria, Ezra A Amsterdam, Dean T. Mason

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The short and long-term antihypertensive action of timolol, a beta blocker, was assessed in 36 mild hypertensives in a 32-wk, double-blind, placebo-controlled study followed by an additional 96 wk of timolol in 17 responders. Diastolic blood pressure (DBP) and heart rate (HR) declined during the first phase from 103 to 93 mm Hg and from 73 to 61 bpm (P < 0.01) but there was no change in systolic blood pressure (SBP). The initial hypotensive responses continued in 17 long-term timolol subjects (DBP 89 mm Hg at 32 wk and 88 mm Hg at 96 wk [NS] and HR 62 and 65 bpm [NS]). Although stimulated plasma renin activity in the entire group decreased from 1.08 to 0.28 ng/ml/hr (P < 0.001), blood pressure reduction did not correlate with this decline (r = 0.29) or with serum timolol level (r = 0.29). In 20 patients who underwent treadmill exercise evaluation, timolol limited exercise HR and duration and work capacity but peak SBP was not altered. Thus, timolol is effective in reducing mild high blood pressure during short-term therapy and in maintaining this effect over the long term in responsive subjects. It is therefore potentially useful in chronic essential hypertension.

Original languageEnglish (US)
Pages (from-to)765-772
Number of pages8
JournalClinical Pharmacology and Therapeutics
Volume30
Issue number6
StatePublished - Dec 1981

Fingerprint

Timolol
Blood Pressure
Therapeutics
Heart Rate
Exercise
Essential Hypertension
Renin
Antihypertensive Agents
Placebos
Hypertension

ASJC Scopus subject areas

  • Pharmacology

Cite this

Harris, F. J., Tonkin, M., Pratt, C., DeMaria, A. N., Amsterdam, E. A., & Mason, D. T. (1981). Short- and long-term therapy of mild essential hypertension with timolol. Clinical Pharmacology and Therapeutics, 30(6), 765-772.

Short- and long-term therapy of mild essential hypertension with timolol. / Harris, Fred J.; Tonkin, Melvin; Pratt, Craig; DeMaria, Anthony N.; Amsterdam, Ezra A; Mason, Dean T.

In: Clinical Pharmacology and Therapeutics, Vol. 30, No. 6, 12.1981, p. 765-772.

Research output: Contribution to journalArticle

Harris, FJ, Tonkin, M, Pratt, C, DeMaria, AN, Amsterdam, EA & Mason, DT 1981, 'Short- and long-term therapy of mild essential hypertension with timolol', Clinical Pharmacology and Therapeutics, vol. 30, no. 6, pp. 765-772.
Harris, Fred J. ; Tonkin, Melvin ; Pratt, Craig ; DeMaria, Anthony N. ; Amsterdam, Ezra A ; Mason, Dean T. / Short- and long-term therapy of mild essential hypertension with timolol. In: Clinical Pharmacology and Therapeutics. 1981 ; Vol. 30, No. 6. pp. 765-772.
@article{ed6bd67e5e444863822c948816e93436,
title = "Short- and long-term therapy of mild essential hypertension with timolol",
abstract = "The short and long-term antihypertensive action of timolol, a beta blocker, was assessed in 36 mild hypertensives in a 32-wk, double-blind, placebo-controlled study followed by an additional 96 wk of timolol in 17 responders. Diastolic blood pressure (DBP) and heart rate (HR) declined during the first phase from 103 to 93 mm Hg and from 73 to 61 bpm (P < 0.01) but there was no change in systolic blood pressure (SBP). The initial hypotensive responses continued in 17 long-term timolol subjects (DBP 89 mm Hg at 32 wk and 88 mm Hg at 96 wk [NS] and HR 62 and 65 bpm [NS]). Although stimulated plasma renin activity in the entire group decreased from 1.08 to 0.28 ng/ml/hr (P < 0.001), blood pressure reduction did not correlate with this decline (r = 0.29) or with serum timolol level (r = 0.29). In 20 patients who underwent treadmill exercise evaluation, timolol limited exercise HR and duration and work capacity but peak SBP was not altered. Thus, timolol is effective in reducing mild high blood pressure during short-term therapy and in maintaining this effect over the long term in responsive subjects. It is therefore potentially useful in chronic essential hypertension.",
author = "Harris, {Fred J.} and Melvin Tonkin and Craig Pratt and DeMaria, {Anthony N.} and Amsterdam, {Ezra A} and Mason, {Dean T.}",
year = "1981",
month = "12",
language = "English (US)",
volume = "30",
pages = "765--772",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Short- and long-term therapy of mild essential hypertension with timolol

AU - Harris, Fred J.

AU - Tonkin, Melvin

AU - Pratt, Craig

AU - DeMaria, Anthony N.

AU - Amsterdam, Ezra A

AU - Mason, Dean T.

PY - 1981/12

Y1 - 1981/12

N2 - The short and long-term antihypertensive action of timolol, a beta blocker, was assessed in 36 mild hypertensives in a 32-wk, double-blind, placebo-controlled study followed by an additional 96 wk of timolol in 17 responders. Diastolic blood pressure (DBP) and heart rate (HR) declined during the first phase from 103 to 93 mm Hg and from 73 to 61 bpm (P < 0.01) but there was no change in systolic blood pressure (SBP). The initial hypotensive responses continued in 17 long-term timolol subjects (DBP 89 mm Hg at 32 wk and 88 mm Hg at 96 wk [NS] and HR 62 and 65 bpm [NS]). Although stimulated plasma renin activity in the entire group decreased from 1.08 to 0.28 ng/ml/hr (P < 0.001), blood pressure reduction did not correlate with this decline (r = 0.29) or with serum timolol level (r = 0.29). In 20 patients who underwent treadmill exercise evaluation, timolol limited exercise HR and duration and work capacity but peak SBP was not altered. Thus, timolol is effective in reducing mild high blood pressure during short-term therapy and in maintaining this effect over the long term in responsive subjects. It is therefore potentially useful in chronic essential hypertension.

AB - The short and long-term antihypertensive action of timolol, a beta blocker, was assessed in 36 mild hypertensives in a 32-wk, double-blind, placebo-controlled study followed by an additional 96 wk of timolol in 17 responders. Diastolic blood pressure (DBP) and heart rate (HR) declined during the first phase from 103 to 93 mm Hg and from 73 to 61 bpm (P < 0.01) but there was no change in systolic blood pressure (SBP). The initial hypotensive responses continued in 17 long-term timolol subjects (DBP 89 mm Hg at 32 wk and 88 mm Hg at 96 wk [NS] and HR 62 and 65 bpm [NS]). Although stimulated plasma renin activity in the entire group decreased from 1.08 to 0.28 ng/ml/hr (P < 0.001), blood pressure reduction did not correlate with this decline (r = 0.29) or with serum timolol level (r = 0.29). In 20 patients who underwent treadmill exercise evaluation, timolol limited exercise HR and duration and work capacity but peak SBP was not altered. Thus, timolol is effective in reducing mild high blood pressure during short-term therapy and in maintaining this effect over the long term in responsive subjects. It is therefore potentially useful in chronic essential hypertension.

UR - http://www.scopus.com/inward/record.url?scp=0019772197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019772197&partnerID=8YFLogxK

M3 - Article

C2 - 7030579

AN - SCOPUS:0019772197

VL - 30

SP - 765

EP - 772

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 6

ER -