Shock Wave-Induced Damage of a Protein by Void Collapse

Edmond Y Lau, Max L. Berkowitz, Eric Schwegler

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study, we report on a series of molecular dynamics simulations that were used to examine the effects of shock waves on a membrane-bound ion channel. A planar shock wave was found to compress the ion channel upon impact, but the protein geometry resembles the crystal structure as soon as the solvent density begins to dissipate. When a void was placed in close proximity to the membrane, the shock wave proved to be more destructive to the protein due to formation of a nanojet that results from the asymmetric collapse of the void. The nanojet was able to cause significant structural changes to the protein even at low piston velocities that are not able to directly cause poration of the membrane.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalBiophysical Journal
Volume110
Issue number1
DOIs
StatePublished - Jan 5 2016
Externally publishedYes

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Ion Channels
Membranes
Proteins
Molecular Dynamics Simulation

ASJC Scopus subject areas

  • Biophysics

Cite this

Shock Wave-Induced Damage of a Protein by Void Collapse. / Lau, Edmond Y; Berkowitz, Max L.; Schwegler, Eric.

In: Biophysical Journal, Vol. 110, No. 1, 05.01.2016, p. 147-156.

Research output: Contribution to journalArticle

Lau, Edmond Y ; Berkowitz, Max L. ; Schwegler, Eric. / Shock Wave-Induced Damage of a Protein by Void Collapse. In: Biophysical Journal. 2016 ; Vol. 110, No. 1. pp. 147-156.
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