Abstract
PURPOSE: To define the magnetic resonance (MR) imaging appearance of shell osteochondral allografts of the knee and compare the MR findings with antibody responses. MATERIALS AND METHODS: Thirty-six grafts were evaluated with a 1.5-T unit with T1-, intermediate-, and T2-weighted, and three-dimensional spoiled gradient-recalled MR imaging at 3, 6, 12, 24, and/or 36 months after surgery. Nineteen patients underwent imaging serially. Two osteoradiologists scored by consensus host marrow edema, thickness of graft-host interface, signal intensity of graft marrow, cyst formation, joint effusion, articular cartilage defects, and surface collapse. Patients were divided into antibody-positive (AP) (n = 11) and antibody-negative (AN) (n = .25) groups evenly distributed across the different time points on the basis of results of anti-human leukocyte antigen antibody screening. MR findings for the two groups were compared. RESULTS: AP patients demonstrated greater mean edema (P < .002), thicker interface (P < .03), and more abnormal graft marrow (P < .04) than AN patients, and they had a higher proportion of surface collapse (P < .03). CONCLUSION: Humoral immune responses were associated with more inflammation and less complete incorporation after allograft placement. MR imaging shows promise as a surrogate biomarker for success of shell osteochondral allograft implantation.
Original language | English (US) |
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Pages (from-to) | 35-43 |
Number of pages | 9 |
Journal | Radiology |
Volume | 219 |
Issue number | 1 |
State | Published - 2001 |
Keywords
- Antibodies
- Bones grafts
- Immunity
- Knee, ligaments, menisci and cartilage
- Knee, MR
ASJC Scopus subject areas
- Radiological and Ultrasound Technology