Shared Antigens on Acetylcholine Receptor and Bacterial Proteins

C. I.Edvard Smith, Lennart Hammarström, Donard S. Dwyer, Kari Stefansson, Michael E. Dieperink, Christopher M. Gomez, David P Richman, Linda S. Marton

Research output: Contribution to journalLetterpeer-review


To the Editor: The report by Stefansson et al. (Jan. 24 issue) describes the sharing of antigenic determinants between the nicotinic acetylcholine receptor and three bacterial proteins.1 Their conclusion is based on the analysis of 22 IgG and 4 IgM rat monoclonal antibodies directed against the acetylcholine receptor, and the authors point to the possibility that the primary event in myasthenia gravis is the induction of antibacterial antibodies. This hypothesis may well turn out to be correct, but there is one problem that needs more discussion. In the study by Stefansson et al., the two cross-reactive monoclonal antibodies were both.

Original languageEnglish (US)
Pages (from-to)389-390
Number of pages2
JournalNew England Journal of Medicine
Issue number6
StatePublished - Aug 8 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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